Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids

Murraya koenigii leaves (Rutaceae) are used traditionally in Indian Ayurvedic system to treat diabetes. The purpose of the study is to investigate the effect of mahanimbine (carbazole alkaloid from Murraya koenigii leaves) on blood glucose and serum lipid profiles on streptozotocin-induced diabetic rats. Diabetes was induced in adult male Wistar rats by intra-peritoneal injection of streptozotocin (45mg/kg). Mahanimbine (50 and 100mg/kg) were administrated as a single dose per week to the diabetic rats for 30 days. The control group received 0.3% w/v sodium carboxy methyl cellulose for the same duration. Fasting blood sugar and serum lipid profiles were measured in the diabetic and non-diabetic rats. In addition, in vitro alpha amylase and alpha glucosidase inhibitory effects of mahanimbine were performed. Results: In the diabetic rats, the elevated fasting blood sugar, triglycerides, low density lipoprotein, very low density lipoprotein levels were reduced and high density lipoprotein level was increased by mahanimbine at a dose of 50 and 100mg/kg (i.p). In addition, mahanimbine showed appreciable alpha amylase inhibitory effect and weak alpha glucosidase inhibitory effects when compared with acarbose. Conclusions: The present study indicated that mahanimbine possess anti-hyperglycemic and anti-lipidemic effects. Thus results suggesting mahanimbine has beneficial effect in the management of diabetes associated with abnormal lipid profile and related cardiovascular complications. Keywords: Streptozotocin; Hypoglycemic; Hypolipidemic; Mahanimbine

http://arjournals.org/index.php/ijpm/article/viewFile/82/76

Antidiabetic and hypolipidemic effects of mahanimbine (carbazole alkaloid) from murraya koenigii (rutaceae) leaves

Medicinal plants are used in herbalism and thought to have some medicinal properties. They form the easily available source for healthcare purposes in rural and tribal areas. Ethanobotany is a distinct branch of natural science dealing with various aspects such as anthropology, archaeology, botany, ecology, economics and medicine, religious, cultural and several other disciplines. Recently, great interest in the above given studies of herbal drugs and traditional remedies is indicated worldwide and there has been an upsurge in the scientific investigations in this area. The Murraya koenigii plant is widely used as herb, spice, condiments and also used to treat various types of ailments in Indian traditional system. World’s about 80% population relies upon herbal products, because they have been considered as safe, effective and economical. The present study was aimed to review the ethanobotanical properties, pharmacognostic, phytochemical and pharmacological properties of Murraya koenigii plant. The various parts of this plant are widely used by different tribal communities. The leaves of plant are use as tonic, stomachic, carminative, internally in dysentery, vomiting. Used as antihelminthic, analgesic, cures piles, allays heat of the body, thirst, inflammation and itching. Following various claims for cure of numerous diseases, efforts have been made by researchers to verify the efficacy of the plant through scientific biological screening. A scrutiny of literature reveals some notable pharmacological activities of the plant such as activity on heart, anti diabetic and cholesterol reducing property, antimicrobial activity, antiulcer activity, antioxidative property, cytotoxic activity, anti diarrhea activity, phagocytic activity and many more medicinal values.

A review on murraya koenigii: multipotential medicinal plant

Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid.

Mushrooms are well known for their nutritional as well as therapeutic values worldwide. Interest in mushrooms has peaked because immunity and cellular protection are important issues for health conscious consumers and for those individuals who are dealing with serious health issues. Mushrooms generally belong to Basidiomycetes which harbors numerous mushroom species with diversity of metabolites of nutraceutical and therapeutic significance. They have been reported to be the most valuable ones for humans. Investigations on the therapeutic and nutritional properties of mushrooms are underway throughout the world. Researchers are providing crucial data on the array of bioactive compounds found within these fascinating fungi. People are now accepting mushrooms more as food and food supplements. Various academic and research institutes are all involved actively in research on bioactive metabolites of mushrooms. The present paper aims at reviewing the diversity of mushrooms and the types of metabolites especially of nutraceutical and therapeutic importance present in these mushrooms and their role as bioactive agents.

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Diversity of Mushrooms and Their Metabolites of Nutraceutical and Therapeutic Significance

Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds

A new carbazole alkaloid (kurryam) oxygenated at the 4-position, hitherto unknown among carbazole alkaloids, has been isolated from the seeds of an Indian medicinal plant, Murraya koenigii (Rutacea...

https://journals.sagepub.com/doi/pdf/10.1177/1934578X0800301019

Samir K. Banerjee

Papers

Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds

A New Carbazole Alkaloid from Murraya koenigii Spreng (Rutaceae)