Purpose:To evaluate the prevalence of the most common serious adverse events associated with intravitreous (IVT) injection.Methods:A systematic search of the literature via PubMed from 1966 to March 1, 2004, was conducted to identify studies evaluating the safety of IVT injection. Data submitted in

Risks of intravitreous injection: a comprehensive review.

Complications associated with the use of silicone oil in 150 eyes after retina-vitreous surgery.

Silicone oil in the repair of complex retinal detachments. a prospective observational multicenter study

Background: The Silicone Study evaluated the outcomes of vitreoretinal surgery for retinal detachment with proliferative vitreoretinopathy (PVR). Objective: To evaluate short-term (up to 36 months) outcomes in eyes randomized to silicone oil or perfluoropropane gas and long-term (up to 72 months) outcomes in eyes with attached maculas at 36 months. Design: Prospective, randomized, multicentered surgical trial. Setting: Community- and university-based vitreoretinal practices. Patients: Two-hundred sixty-five eyes with PVR randomized to perfluoropropane gas and silicone oil with follow-up through 3 years (cohort 1) and 249 eyes with attached maculas at 36 months (121 eyes randomized to long-acting gas [either sulfur hexafluoride or perfluoropropane] and 128 eyes randomized to silicone oil) with follow-up up to 6 years (cohort 2). Both cohorts consisted of eyes that had and had not undergone vitrectomy for PVR (groups 1 and 2, respectively) before randomization. Of the 265 eyes in cohort 1, 24-month follow-up data were available for 218 eyes (82%) and 36-month follow-up data were available for 196 eyes (74%). Of 208 eyes in cohort 2, 48-month follow-up data were available for 146 eyes (70%), 60-month follow-up data for 119 eyes (57%), and 72-month follow-up data for 73 eyes (35%). Interventions: Vitrectomy surgery for PVR with a long-acting gas or silicone oil as the intraocular tamponade. Main Outcome Measures: Changes in visual acuity, recurrent retinal detachment, and incidence of complications. Results: In group 1 of cohort 1, compared with oiltreated eyes, gas-treated eyes had a higher rate of complete retinal reattachment from 18 to 36 months ( P P P =.02). Compared with oil-retained eyes, oil-removed eyes had higher rates of complete posterior attachment ( P =.01) and of a visual acuity of 5/200 or better ( P P P P Conclusion: The Silicone Study showed that silicone oil and perfluoropropane gas were equal in most respects for the management of retinal detachments with PVR. Success in the first surgery for PVR is paramount for obtaining better visual results. Overall, surgery for PVR had a high likelihood of retinal reattachment, and if anatomically and visually successful at 3 years, there is an excellent chance that the results will be maintained over the long-term.

Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow-up. Silicone Study report 11.

Temporary Silicone Oil Tamponade in the Management of Retinal Detachment with Proliferative Vitreoretinopathy

Introduction Silicone rubber has been widely used as implant material in plastic surgery and in retinal detachment procedures. 1 Liquid silicone was first injected into the vitreous cavity of rabbits by Stone, 2 who reported that silicone fluids of various viscosities were well tolerated and produced "very little change in the rabbit eyes over a period of two years." He went on to predict that it might be possible to find a "viscosity" that would maintain the "clarity" of the vitreous and help in "replacing the retina." Recently, other investigators 3-5 have confirmed Stone's observations. However, their animal experiments emphasized the possibilities of complications. Everett 4 reported cataract formation following the injection of liquid silicone into the vitreous cavity of rabbits; Galavin 5 produced glaucoma by the injection of liquid silicone into the posterior chamber of the rabbit eye. The present study serves a dual purpose: (1) to report further

https://jamanetwork.com/journals/jamaophthalmology/articlepdf/627022/archopht_68_5_005.pdf

Samuel Canaan

Papers

The use of liquid silicone in retinal detachment surgery.