S
Samuel Gebre-Medhin
Researcher at Lund University
Publications - 33
Citations - 4158
Samuel Gebre-Medhin is an academic researcher from Lund University. The author has contributed to research in topics: Islet & Amylin. The author has an hindex of 21, co-authored 31 publications receiving 3926 citations. Previous affiliations of Samuel Gebre-Medhin include Karolinska University Hospital & University of Gothenburg.
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Journal ArticleDOI
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.
Per Levéen,Milos Pekny,Samuel Gebre-Medhin,Birgitta Swolin,Erik G. Larsson,Christer Betsholtz +5 more
TL;DR: It is shown that mice deficient for PDGF B die perinatally and display several anatomical and histological abnormalities, and it is concluded thatPDGF B has crucial roles in vivo in establishing certain renal and circulatory functions.
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PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Hans Boström,Karen Willetts,Karen Willetts,Milos Pekny,Per Levéen,Per Lindahl,Håkan Hedstrand,Marcela Pekna,Mats Hellström,Samuel Gebre-Medhin,Martin Schalling,Mia Nilsson,Siri Kurland,Jan Törnell,John K. Heath,Christer Betsholtz +15 more
TL;DR: The two PDGF null phenotypes reveal analogous morphogenetic functions for myofibroblast-type cells in lung and kidney organogenesis, and show that PDGF-B is required in the ontogeny of kidney mesangial cells.
Journal ArticleDOI
Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development
Per Lindahl,Linda Karlsson,Mats Hellström,Samuel Gebre-Medhin,Karen Willetts,John K. Heath,Christer Betsholtz +6 more
TL;DR: It is proposed that lung PDGF-Ralpha+ cells are progenitors of the tropoelastin-positive alveolar SMC, and postnatal alveogenesis failure in PD GF-A(-/-) mice is due to a prenatal block in the distal spreading of PDGF+ cells along the tubular lung epithelium during the canalicular stage of lung development.
Journal ArticleDOI
Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice
Russell D. Brown,Anna Ollerstam,Björn Johansson,Ole Skøtt,Samuel Gebre-Medhin,Bertil B. Fredholm,A. Erik G. Persson +6 more
TL;DR: It is demonstrated that adenosine acting on A1R is required for TGF and modulates renin release.
Journal ArticleDOI
Vascular Endothelial Growth Factor-B–Deficient Mice Display an Atrial Conduction Defect
Karin Aase,Gabriel von Euler,Xuri Li,Annica Pontén,Peter Thorén,Renhai Cao,Yihai Cao,Birgitta Olofsson,Samuel Gebre-Medhin,Milos Pekny,Kari Alitalo,Christer Betsholtz,Ulf Eriksson +12 more
TL;DR: VEGF-B seems to be required for normal heart function in adult animals but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.