scispace - formally typeset
Search or ask a question

Showing papers by "Samuel Graham published in 1988"

Patent•
Thiophene sulfonamide antiglaucoma agents

[...]

Baldwin John J1, Wasyl Halczenko1, Charles N. Habecker1, George D. Hartman1, Samuel Graham1, Harvey Schwam1, Gerald S. Ponticello1, Kenneth L. Shepard1 •
Merck & Co.1
06 Jun 1988
TL;DR: Aryl (or aralkyl)-sulfonylthiophene-2-sulfonamides containing a basic functional group as a substituent are efficacious in the treatment of elevated intraocular pressure and glaucoma following topical ocular administration as mentioned in this paper.
Abstract: Aryl (or aralkyl)-sulfonylthiophene-2-sulfonamides containing a basic functional group as a substituent are efficacious in the treatment of elevated intraocular pressure and glaucoma following topical ocular administration.

11 citations

Patent•
Novel intermediates and processes for preparing hmg-coa reductase inhibitors

[...]

Samuel Graham1, Thomas H. Scholz1•
Merck & Co.1
20 Jun 1988
TL;DR: A process for converting 6-carboxy to 6-hydroxymethyl mevinolin analogs and novel intermediates formed in this process are disclosed in this paper, where the authors also present a novel intermediate.
Abstract: A process for converting 6-carboxy to 6-hydroxymethyl mevinolin analogs and novel intermediates formed in this process are disclosed.