Author
Sandeep Sarabu
Other affiliations: Kakatiya University
Bio: Sandeep Sarabu is an academic researcher from University of Mississippi. The author has contributed to research in topics: Solubility & Differential scanning calorimetry. The author has an hindex of 11, co-authored 21 publications receiving 261 citations. Previous affiliations of Sandeep Sarabu include Kakatiya University.
Papers
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TL;DR: This review attempts to discuss the important and industrially scalable thermal strategies for the development of amorphous solid dispersion using both solvent (spray drying and fluid bed processing) and fusion (hot melt extrusion and KinetiSol®) based techniques.
50 citations
TL;DR: The hot melt extrusion (HME) is a promising technology in the pharmaceutical industry, as evidenced by its application to manufacture various FDA-approved commercial products i.e., drugs as discussed by the authors.
Abstract: Introduction: Currently, hot melt extrusion (HME) is a promising technology in the pharmaceutical industry, as evidenced by its application to manufacture various FDA-approved commercial products i...
47 citations
TL;DR: The inhibitory effect of HPMCAS on drug precipitation was dependent on the hydrophobic interactions between drug and polymer, polymer grade, and the dissolution dose of the drug.
46 citations
TL;DR: An overview of various stress conditions that proteins might encounter during lyophilization process, mechanisms to improve the stability and analytical techniques to tackle the proteins instability during both freeze-drying and storage is provided.
44 citations
TL;DR: This novel study not only discusses the incorporation of acidifiers in SDs but also the preparation of SDs using HME technology as effective techniques to improve drug release and bioavailability.
42 citations
Cited by
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TL;DR: This review discussed the methodologies of preparation and characterization of ASDs with an emphasis on understanding and predicting stability, and rational selection of polymers, preparation techniques with its advantages and disadvantages and characterize of polymeric amorphous solid dispersions.
138 citations
TL;DR: This review provides an updated overview of manufacturing techniques for preparing ASDs, and selection strategies are proposed to identify suitable manufacturing methods, which may aid in the development of ASDs with satisfactory physical stability.
136 citations
TL;DR: FDM 3D printing is a potential technique for the development of complex customized drug delivery systems for personalized pharmacotherapy by developing novel core-shell gastroretentive floating pulsatileDrug delivery systems using a hot-melt extrusion-paired fused deposition modeling (FDM)3D printing and direct compression method.
Abstract: This study was performed to develop novel core-shell gastroretentive floating pulsatile drug delivery systems using a hot-melt extrusion-paired fused deposition modeling (FDM) 3D printing and direct compression method. Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC)-based filaments were fabricated using hot-melt extrusion technology and were utilized as feedstock material for printing shells in FDM 3D printing. The directly compressed theophylline tablet was used as the core. The tablet shell to form pulsatile floating dosage forms with different geometries (shell thickness: 0.8, 1.2, 1.6, and 2.0 mm; wall thickness: 0, 0.8, and 1.6 mm; and % infill density: 50, 75, and 100) were designed, printed, and evaluated. All core-shell tablets floated without any lag time and exhibited good floating behavior throughout the dissolution study. The lag time for the pulsatile release of the drug was 30 min to 6 h. The proportion of ethyl cellulose in the filament composition had a significant (p < 0.05) effect on the lag time. The formulation (2 mm shell thickness, 1.6 mm wall thickness, 100% infill density, 0.5% EC) with the desired lag time of 6 h was selected as an optimized formulation. Thus, FDM 3D printing is a potential technique for the development of complex customized drug delivery systems for personalized pharmacotherapy.
86 citations
TL;DR: A systematic step-by-step approach is presented, where thermodynamics, polymer screening, multivariate statistics and process optimization are combined, to increase the success of HME-based drug product development.
76 citations
TL;DR: Hot melt extrusion was coupled with 3D printing to develop a unique gastro retentive dosage form to personalize treatment of cinnarizine or other narrow absorption window drugs to meet individual patient needs.
64 citations