S
Sander Boymans
Researcher at Utrecht University
Publications - 26
Citations - 2820
Sander Boymans is an academic researcher from Utrecht University. The author has contributed to research in topics: Adult stem cell & Stem cell. The author has an hindex of 13, co-authored 25 publications receiving 2280 citations. Previous affiliations of Sander Boymans include University Medical Center Utrecht.
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Journal ArticleDOI
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
Gerald Schwank,Bon-Kyoung Koo,Valentina Sasselli,Johanna F. Dekkers,Inha Heo,Turan Demircan,Nobuo Sasaki,Sander Boymans,Edwin Cuppen,Cornelis K. van der Ent,Edward E. S. Nieuwenhuis,Jeffrey M. Beekman,Hans Clevers +12 more
TL;DR: The CRISPR/Cas9 genome editing system is used to correct the CFTR locus by homologous recombination in cultured intestinal stem cells of CF patients and the corrected allele is expressed and fully functional as measured in clonally expanded organoids.
Journal ArticleDOI
Tissue-specific mutation accumulation in human adult stem cells during life
Francis Blokzijl,Joep de Ligt,Myrthe Jager,Valentina Sasselli,Sophie Roerink,Nobuo Sasaki,Meritxell Huch,Sander Boymans,Ewart W. Kuijk,Pjotr Prins,Isaac J. Nijman,Inigo Martincorena,Michal Mokry,Caroline L. Wiegerinck,Sabine Middendorp,Toshiro Sato,Gerald Schwank,Edward E. S. Nieuwenhuis,Monique M A Verstegen,Luc J. W. van der Laan,Jeroen de Jonge,Jan N. M. IJzermans,Robert G.J. Vries,Marc van de Wetering,Michael R. Stratton,Hans Clevers,Edwin Cuppen,Ruben van Boxtel +27 more
TL;DR: This work determines genome-wide mutation patterns in ASCs of the small intestine, colon and liver of human donors with ages ranging from 3 to 87 years by sequencing clonal organoid cultures derived from primary multipotent cells.
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Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes
Sebastiaan van Heesch,Maarten van Iterson,Jetse Jacobi,Sander Boymans,Paul B. Essers,Ewart de Bruijn,Wensi Hao,Alyson W. MacInnes,Edwin Cuppen,Marieke Simonis +9 more
TL;DR: The findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes.
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5-Fluorouracil treatment induces characteristic T>G mutations in human cancer.
Sharon Christensen,Bastiaan van der Roest,Nicolle Besselink,Roel Janssen,Sander Boymans,John W.M. Martens,Marie-Laure Yaspo,Peter Priestley,Ewart W. Kuijk,Edwin Cuppen,Arne Van Hoeck +10 more
TL;DR: The authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 frequently observed in untreated cancers, which indicates that distinct endogenous and exogenous triggers can converge onto highly similar mutational signatures.
Journal ArticleDOI
Genomic landscape of rat strain and substrain variation
Roel Hermsen,Joep de Ligt,Wim P.E. Spee,Francis Blokzijl,Sebastian Schafer,Eleonora Adami,Sander Boymans,Stephen Flink,Ruben van Boxtel,Robin H. van der Weide,Timothy J. Aitman,Norbert Hubner,Marieke Simonis,Boris Tabakoff,Victor Guryev,Edwin Cuppen +15 more
TL;DR: These genome-wide analyses do not show evidence for contribution of multiple ancestral founder rat subspecies to the currently used rat inbred strains, as is the case for mouse, and the degree of substrain variation is highly variable between strains.