S
Sander R. Piersma
Researcher at VU University Amsterdam
Publications - 173
Citations - 7450
Sander R. Piersma is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Cancer & Kinase. The author has an hindex of 43, co-authored 146 publications receiving 6075 citations. Previous affiliations of Sander R. Piersma include Fundamental Research on Matter Institute for Atomic and Molecular Physics & VU University Medical Center.
Papers
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Journal ArticleDOI
Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins.
Musa Sani,Edith N.G. Houben,Jeroen Geurtsen,Jason Pierson,Karin de Punder,Maaike van Zon,Brigitte Wever,Sander R. Piersma,Connie R. Jimenez,Mamadou Daffé,Ben J. Appelmelk,Wilbert Bitter,Nicole N. van der Wel,Peter J. Peters,Peter J. Peters +14 more
TL;DR: Using plunge freezing cryo-electron microscopy technique, a direct visualization of the mycobacterial capsular layer as a labile structure that contains ESX-1-secreted proteins is shown.
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Gold-Enhanced Biomolecular Surface Imaging of Cells and Tissue by SIMS and MALDI Mass Spectrometry
A. F. Maarten Altelaar,Ivo Klinkert,Kees Jalink,Robert P. J. de Lange,Roger A.H. Adan,Ron M. A. Heeren,Sander R. Piersma +6 more
TL;DR: The results obtained for cells and tissue sections illustrate the potential of this sample preparation technique for biomolecular surface imaging by mass spectrometry.
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PPIB mutations cause severe osteogenesis imperfecta.
Fleur S van Dijk,Isabel M. Nesbitt,Eline H. Zwikstra,Peter G.J. Nikkels,Sander R. Piersma,Silvina A. Fratantoni,Connie R. Jimenez,Margriet Huizer,Alice C. Morsman,Jan Maarten Cobben,Mirjam H.H. van Roij,Mariet W. Elting,Jonathan I.M.L. Verbeke,Liliane C. D. Wijnaendts,Nick Shaw,Wolfgang Högler,Carole McKeown,Erik A. Sistermans,Ann Dalton,Hanne Meijers-Heijboer,Gerard Pals +20 more
TL;DR: It is suggested that recessive OI is caused by a dysfunctional P3H1/CRTAP/CyPB complex rather than by the lack of 3-prolyl hydroxylation of a single proline residue in the alpha1 chains of collagen type I.
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Interaction of myeloperoxidase with peroxynitrite. A comparison with lactoperoxidase, horseradish peroxidase and catalase.
TL;DR: The effect of nitrite on myeloperoxidase was studied and it was concluded that the enzyme reacts with the protonated form of the peroxide, that is peroxynitrous acid, with a pH-independent second-order rate constant of 2.9.
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Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Davide Chiasserini,Jan R.T. van Weering,Sander R. Piersma,Thang V. Pham,Arjan Malekzadeh,Charlotte E. Teunissen,Heidi de Wit,Connie R. Jimenez +7 more
TL;DR: It is shown that human CSF extracellular vesicles contain prionogenic proteins such as the amyloid precursor protein and the prion protein, postulated as one of the mechanisms involved in the spreading of neurodegeneration to different brain areas.