S
Sander Verheule
Researcher at Maastricht University
Publications - 131
Citations - 6540
Sander Verheule is an academic researcher from Maastricht University. The author has contributed to research in topics: Atrial fibrillation & Medicine. The author has an hindex of 39, co-authored 109 publications receiving 5785 citations. Previous affiliations of Sander Verheule include Indiana University & Utrecht University.
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Journal ArticleDOI
Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal
TL;DR: A translational overview on the biological basis of atrial remodeling and the proarrhythmic mechanisms involved in the fibrillation process is given.
Journal ArticleDOI
Increased Vulnerability to Atrial Fibrillation in Transgenic Mice With Selective Atrial Fibrosis Caused by Overexpression of TGF-β1
Sander Verheule,Toshiaki Sato,Thomas H. Everett,Steven K. Engle,Dan Otten,Michael Rubart-von der Lohe,Hisako O. Nakajima,Hidehiro Nakajima,Loren J. Field,Jeffrey E. Olgin +9 more
TL;DR: In this transgenic mouse model, selective atrial fibrosis is sufficient to increase AF inducibility, and action potential characteristics recorded with intracellular microelectrodes did not reveal differences between Wt and Tx mice in either atrium.
Journal ArticleDOI
Arrhythmogenic substrate of the pulmonary veins assessed by high-resolution optical mapping.
Rishi Arora,Sander Verheule,Luis R. Scott,Antonio Navarrete,Vikram Katari,Emily E. Wilson,Dev Vaz,Jeffrey E. Olgin +7 more
TL;DR: The normal PV seems to have the necessary substrate to support reentry as well as focal activity, although reentry occurred more distally in the vein, focal activity seemed to occur more proximally.
Journal ArticleDOI
Alterations in Atrial Electrophysiology and Tissue Structure in a Canine Model of Chronic Atrial Dilatation Due to Mitral Regurgitation
Sander Verheule,Emily E. Wilson,Thomas H. Everett,Sujata M Shanbhag,Catherine Golden,Jeffrey E. Olgin +5 more
TL;DR: In the dilated MR left atrium, areas of increased interstitial fibrosis and chronic inflammation were accompanied by increased glycogen ultrastructurally, leading to an increased vulnerability to AF that is not based on a decrease in wavelength.
Journal ArticleDOI
PITX2c is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression
Paulus Kirchhof,Peter C. Kahr,Sven Kaese,Ilaria Piccini,Ismail Vokshi,H. H. Scheld,Heinrich Rotering,Lisa Fortmueller,Sandra Laakmann,Sander Verheule,Ulrich Schotten,Larissa Fabritz,Nigel A. Brown +12 more
TL;DR: A physiological role for PITx2 in the adult heart is demonstrated and the hypothesis that dysregulation of PITX2 expression can be responsible for susceptibility to atrial fibrillation is supported.