Sandra Cottet

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that apoptosis plays only a minor role in the inherited forms of retinal neurodegeneration studied, where instead, a non-apoptotic degenerative mechanism common to all mutants is of major importance.

TL;DR: Modulation of common apoptotic signaling pathways may be of outstanding potential to target multiple retinal dystrophies regardless of the primary genetic defect and to develop alternative therapies to prevent or inhibit eye defect.

TL;DR: It is demonstrated that IL-1β is involved in inducible nitric oxide synthase gene expression and induction of apoptosis in mouse β cells but does not contribute to impaired glucose-stimulated insulin secretion.