S
Sanjay K. Srivastava
Researcher at Texas Tech University Health Sciences Center
Publications - 430
Citations - 17482
Sanjay K. Srivastava is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Cancer & Aldose reductase. The author has an hindex of 73, co-authored 366 publications receiving 15587 citations. Previous affiliations of Sanjay K. Srivastava include University of Pittsburgh & University of Louisville.
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Journal ArticleDOI
Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties
Piotr Zimniak,Bindu Nanduri,Slawomir Pikula,Joanna Bandorowicz-Pikula,Sharad S. Singhal,Sanjay K. Srivastava,Sanjay Awasthi,Yogesh C. Awasthi +7 more
TL;DR: Data indicate that the residue in position 104 helps to define the geometry of the hydrophobic substrate-binding site, and may also influence activity by interacting with residues directly involved in substrate binding.
Journal ArticleDOI
Sulforaphane-induced Cell Death in Human Prostate Cancer Cells Is Initiated by Reactive Oxygen Species
Shivendra V. Singh,Sanjay K. Srivastava,Sunga Choi,Karen L. Lew,Jedrzej Antosiewicz,Dong Xiao,Yan Zeng,Simon C. Watkins,Candace S. Johnson,Donald L. Trump,Yong J. Lee,Hui Xiao,Anna Herman-Antosiewicz +12 more
TL;DR: The results of the present study indicate that SFN-induced apoptosis in prostate cancer cells is initiated by ROS generation and that both intrinsic and extrinsic caspase cascades contribute to the cell death caused by this highly promising cancer chemopreventive agent.
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Sulforaphane-induced G2/M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation of Cell Division Cycle 25C
Shivendra V. Singh,Anna Herman-Antosiewicz,Ajita V. Singh,Karen L. Lew,Sanjay K. Srivastava,Ravindra Kamath,Kevin D. Brown,Lin Zhang,R. Baskaran +8 more
TL;DR: It is demonstrated that SFN treatment causes an irreversible arrest in the G2/M phase of the cell cycle, and activation of checkpoint kinase 2 (Chk2) plays a major role in irreversible G 2/M arrest by SFN.
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Arsenic and Cardiovascular Disease
TL;DR: Data suggest that nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide or its derivatives are essential second messengers in the signaling pathway for arsenic-stimulated vessel remodeling and future directions for research into the cardiovascular effects of arsenic exposure are provided.
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In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
TL;DR: Results show that capsaicin is an effective inhibitor of in vitro and in vivo growth of pancreatic cancer cells and provide the rationale for further clinical investigation of Capsaicin against pancreaticcancer.