S
Santos A. Susin
Researcher at French Institute of Health and Medical Research
Publications - 152
Citations - 33782
Santos A. Susin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Apoptosis & Mitochondrion. The author has an hindex of 74, co-authored 148 publications receiving 32846 citations. Previous affiliations of Santos A. Susin include Paris Descartes University & University of Paris.
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Journal ArticleDOI
Molecular characterization of mitochondrial apoptosis-inducing factor
Santos A. Susin,Hans K. Lorenzo,Naoufal Zamzami,Isabel Marzo,Bryan E. Snow,Joan Mangion,Etienne Jacotot,Paola Costantini,Markus Loeffler,Nathanael Larochette,David R. Goodlett,Ruedi Aebersold,David P. Siderovski,Josef M. Penninger,Guido Kroemer +14 more
TL;DR: The identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei is reported, indicating that AIF is a mitochondrial effector of apoptotic cell death.
Journal ArticleDOI
Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.
Naoufal Zamzami,Philippe Marchetti,Maria Castedo,Didier Decaudin,Antonio Macho,Tamara Hirsch,Santos A. Susin,Patrice X. Petit,Bernard Mignotte,Guido Kroemer +9 more
TL;DR: Assessment of mitochondrial ROS generation provides an accurate picture of PCD-mediated lymphocyte depletion and indicates alterations of mitochondrial function constitute an important feature of early PCD.
Journal ArticleDOI
Mitochondrial control of apoptosis
TL;DR: It is demonstrated that mitochondrial membrane permeabilization (MMP) constitutes a decisive step of the apoptotic process, and several apoptogenic proteins normally confined to mitochondria are released in the extra-mitochondrial space and participate in the suicidal dismantling of the cell.
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Mitochondrial control of nuclear apoptosis
Naoufal Zamzami,Santos A. Susin,Philippe Marchetti,Tamara Hirsch,I. Gomez-Monterrey,Maria Castedo,Guido Kroemer +6 more
TL;DR: Direct evidence is presented indicating that mitochondrial PT constitutes a critical early event of the apoptotic process, and a specific ligand of the mitochondrial adenine nucleotide translocator, bongkreik acid, inhibits PT and reduces apoptosis induction by mitochondria in a cell-free system.
Journal ArticleDOI
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Nicholas Joza,Nicholas Joza,Santos A. Susin,Eric Daugas,William L. Stanford,Sarah K. Cho,Carol Y. J. Li,Takehiko Sasaki,Takehiko Sasaki,Andrew J. Elia,H.-Y. Mary Cheng,H.-Y. Mary Cheng,Luigi Ravagnan,Karine F. Ferri,Naoufal Zamzami,Andrew Wakeham,Razqallah Hakem,Hiroki Yoshida,Young-Yun Kong,Tak W. Mak,Juan Carlos Zúñiga-Pflücker,Guido Kroemer,Josef M. Penninger,Josef M. Penninger +23 more
TL;DR: It is shown that genetic inactivation of AIF renders embryonic stem cells resistant to cell death after serum deprivation, providing genetic evidence for a caspase-independent pathway of programmed cell death that controls early morphogenesis.