Saqib Anwar

Bio: Saqib Anwar is an academic researcher from King Saud University. The author has contributed to research in topics: Machining & Surface roughness. The author has an hindex of 15, co-authored 66 publications receiving 725 citations. Previous affiliations of Saqib Anwar include University of Nottingham.

Recent Advances in the Machining of Titanium Alloys using Minimum Quantity Lubrication (MQL) Based Techniques

Abstract: Titanium alloys are generally known as difficult-to-machine materials because of their low machinability ratings. Their usage is favored for demanding sectors because of their high strength to weight ratio, high corrosion resistance and ability to operate at elevated temperatures. Machining of titanium alloys results in higher environmental burden, because they require high energy and generous amount of cutting fluids during machining. It is a well-known fact that most of the cutting fluids are toxic and non-biodegradable in nature and their disposal is costly. Therefore, researchers in metal cutting are keen to explore the potential of minimum quantity lubrication (MQL) and minimum quantity cooling lubrication (MQCL) based cooling techniques as an alternate to conventional flood cooling. When MQL and MQCL techniques are used by employing biodegradable vegetable based oils then there is an encouraging potential of replacing the non-biodegradable cutting fluids. This study documents the recent experimental and numerical advances achieved in the MQL and MQCL assisted techniques for machining titanium alloys. The study also highlights the current challenges in this area and recommends future work to address these challenges.

Mathematical modelling of abrasive waterjet footprints for arbitrarily moving jets: Part I—single straight paths

Abstract: It is notoriously well-known that abrasive waterjet milling (AWJM) is difficult to perform controlled-depth owing to variable geometries of the footprints that depends not only on jet energy and the exposure time upon the workpiece, but also on the orientation of the jet relative to the target surface. An attempt is made to develop a model that can be generally applied to different machine system and to predict individual jet footprints that are one of the key steps for controlled-depth AWJM. To address this, the paper breaks new ground in geometrical modelling of AWJM with the benefit of having few variables for predicting the footprints obtained under the following conditions: (i) any time exposures (i.e. Vf, jet feed speeds); (ii) jet orientations (θ) relative to the target surface; (iii) arbitrarily moving straight jet-paths (β). These conditions reflect the real industrial conditions under which the process is run. The geometrical model results in a non-linear partial differential equation, a method to evaluate the material specific erosion rate from the characteristics of a shallow trench obtained experimentally using high jet feed speeds. Under these conditions, the governing equations can be linearised and solved analytically. The model validation for full profile of trenches generated at various tilt angles (θ=70–90°), jet feed rates (Vf=500–1000 mm/min) and jet path directions (β=0–270°) indicates that a high degree of accuracy (mean of the residuals RM

The Design and Analysis of Experiments

Abstract: THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

Conceptualising sustainability assessment

Abstract: Sustainability assessment is being increasingly viewed as an important tool to aid in the shift towards sustainability. However, this is a new and evolving concept and there remain very few examples of effective sustainability assessment processes implemented anywhere in the world. Sustainability assessment is often described as a process by which the implications of an initiative on sustainability are evaluated, where the initiative can be a proposed or existing policy, plan, programme, project, piece of legislation, or a current practice or activity. However, this generic definition covers a broad range of different processes, many of which have been described in the literature as 'sustainability assessment'. This article seeks to provide some clarification by reflecting on the different approaches described in the literature as being forms of sustainability assessment, and evaluating them in terms of their potential contributions to sustainability. Many of these are actually examples of 'integrated assessment', derived from environmental impact assessment (EIA) and strategic environmental assessment (SEA), but which have been extended to incorporate social and economic considerations as well as environmental ones, reflecting a 'triple bottom line' (TBL) approach to sustainability. These integrated assessment processes typically either seek to minimise 'unsustainability', or to achieve TBL objectives. Both aims may, or may not, result in sustainable practice. We present an alternative conception of sustainability assessment, with the more ambitious aim of seeking to determine whether or not an initiative is actually sustainable. We term such processes 'assessment for sustainability'. 'Assessment for sustainability' firstly requires that the concept of sustainability be well-defined. The article compares TBL approaches and principles-based approaches to developing such sustainability criteria, concluding that the latter are more appropriate, since they avoid many of the inherent limitations of the triple-bottom-line as a conception of sustainability.

Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/Nanog axis

Abstract: Emerging evidence have illustrated the vital role of long noncoding RNAs (lncRNAs) long intergenic non-protein coding RNA 00511 (LINC00511) on the human cancer progression and tumorigenesis. However, the role of LINC00511 in breast cancer tumourigenesis is still unknown. This research puts emphasis on the function of LINC00511 on the breast cancer tumourigenesis and stemness, and investigates the in-depth mechanism. The lncRNA and RNA expression were measured using RT-PCR. Protein levels were measured using western blotting analysis. CCK-8, colony formation assays and transwell assay were performed to evaluate the cell proliferation ability and invasion. Sphere-formation assay was also performed for the stemness. Bioinformatic analysis, chromatin immunoprecipitation (ChIP) and luciferase reporter assays were carried to confirm the molecular binding. LINC00511 was measured to be highly expressed in the breast cancer specimens and the high-expression was correlated with the poor prognosis. Functionally, the gain and loss-of-functional experiments revealed that LINC00511 promoted the proliferation, sphere-formation ability, stem factors (Oct4, Nanog, SOX2) expression and tumor growth in breast cancer cells. Mechanically, LINC00511 functioned as competing endogenous RNA (ceRNA) for miR-185-3p to positively recover E2F1 protein. Furthermore, transcription factor E2F1 bind with the promoter region of Nanog gene to promote it transcription. In conclusion, our data concludes that LINC00511/miR-185-3p/E2F1/Nanog axis facilitates the breast cancer stemness and tumorigenesis, providing a vital insight for them.

Eco-Friendly Cutting Fluids in Minimum Quantity Lubrication Assisted Machining: A Review on the Perception of Sustainable Manufacturing

Abstract: In modern days, the conception of sustainability has progressively advanced and has begun receiving global interest. Thus, sustainability is an imperative idea in modern research. Considering the recent trend, this review paper presents a summary of the previously published research articles on minimum quantity lubrication (MQL) assisted machining. The requirement to stir towards sustainability motivated the researchers to revise the effects of substitute lubrication methods on the machining. Conventional lubri-cooling agents are still extensively employed when machining of engineering alloys, but the majority of the recent papers have depicted that the utilization of vegetable oil, nanofluids, and nanoplatelets in MQL system confers superior machining performances as compared to conventional lubrication technology. In actual, the definite principle of this manuscript is to re-examine modern advancements in the MQL technique and also explore the benefits of the vegetable oil and nanofluid as a lubricant. In brief, this paper is a testimony to the advancing capabilities of eco-friendly MQL technique which is a viable alternative to the flood lubrication technology, and the outcomes of this review work can be contemplated as a movement towards sustainable machining.