S
Sarah Baxendale
Researcher at University of Sheffield
Publications - 47
Citations - 15877
Sarah Baxendale is an academic researcher from University of Sheffield. The author has contributed to research in topics: Zebrafish & Gene. The author has an hindex of 21, co-authored 42 publications receiving 15225 citations. Previous affiliations of Sarah Baxendale include Lincoln's Inn.
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Journal ArticleDOI
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
Marcy E. MacDonald,Christine Ambrose,Mabel P. Duyao,Richard H. Myers,Carol Lin,Lakshmi Srinidhi,Glenn Barnes,Sherryl A.M. Taylor,Marianne James,Nicolet Groot,Heather MacFarlane,Barbara Jenkins,Mary Anne Anderson,Nancy S. Wexler,James F. Gusella,Gillian P. Bates,Sarah Baxendale,Holger Hummerich,Susan F. Kirby,Mike North,S. Youngman,Richard Mott,Günther Zehetner,Zdenek Sedlacek,Annemarie Poustka,Anna-Maria Frischauf,Hans Lehrach,Alan Buckler,Deanna M. Church,Lynn Doucette-Stamm,Michael Conlon O'Donovan,Laura Riba-Ramirez,Manish A. Shah,Vincent P. Stanton,Scott A. Strobel,Karen M. Draths,Jennifer L. Wales,Peter B. Dervan,David E. Housman,Michael R. Altherr,Rita Shiang,Leslie M. Thompson,Thomas J. Fielder,John J. Wasmuth,Danilo A. Tagle,John Valdes,Lawrence W. Elmer,Marc W. Allard,Lucio H. Castilla,Manju Swaroop,Kris Blanchard,Francis S. Collins,Russell G. Snell,Tracey Holloway,Kathleen Gillespie,Nicole A. Datson,Duncan Shaw,Peter S. Harper +57 more
TL;DR: In this article, the authors used haplotype analysis of linkage disequilibrium to spotlight a small segment of 4p16.3 as the likely location of the defect, which is expanded and unstable on HD chromosomes.
Journal Article
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
Manish A. Shah,Nicole A. Datson,Lakshmi Srinidhi,Vincent P. Stanton,Marcy E. MacDonald,Marc W. Allard,S. Youngman,Anna-Maria Frischauf,Richard Mott,KM Draths,Günther Zehetner,C. O’Donovan,Thomas J. Fielder,Bruce G. Jenkins,Manju Swaroop,Sherryl A.M. Taylor,Lynn Doucette-Stamm,Heather MacFarlane,Scott A. Strobel,H. E. McFarlane,Alan Buckler,Nicolet Groot,Holger Hummerich,Deanna M. Church,M. A. Anderson,Marianne James,Glenn Barnes,M. Christine,Francis S. Collins,Mabel P. Duyao,Peter B. Dervan,Gillian P. Bates,T Holloway,Peter S. Harper,TW Mcdonald,M North,K Blanchard,John J. Wasmuth,D. Shaw,Hans Lehrach,Danilo A. Tagle,Annemarie Poustka,David E. Housman,T. Huntington,Zdenek Sedlacek,Laura Riba,Susan F. Kirby,Carol Lin,Richard H. Myers,Leslie M. Thompson,Russell G. Snell,Michael Conlon O'Donovan,K Gillespie,Rita Shiang,Nancy S. Wexler,Christine Ambrose,J. F. Gusella,Sarah Baxendale,N. Groat,John Valdes +59 more
TL;DR: The Huntington's disease mutation involves an unstable DNA segment, similar to those described in fragile X syndrome, spino-bulbar muscular atrophy, and myotonic dystrophy, acting in the context of a novel 4p16.3 gene to produce a dominant phenotype.
Journal ArticleDOI
Structure and expression of the Huntington's disease gene: Evidence against simple inactivation due to an expanded CAG repeat
Christine Ambrose,Mabel P. Duyao,Glenn Barnes,Gillian P. Bates,Carol Lin,Jayalakshmi Srinidhi,Sarah Baxendale,Holger Hummerich,Hans Lehrach,Michael R. Altherr,John J. Wasmuth,Alan Buckler,Deanna Church,David E. Housman,Mary Berks,Gos Micklem,Richard Durbin,Alan Dodge,Andrew P Read,James F. Gusella,Marcy E. MacDonald +20 more
TL;DR: Observations suggest that the dominant HD mutation either confers a new property on the mRNA or alters an interaction at the protein level, suggesting the operation of interacting factors in determining specificity of cell loss.
Journal ArticleDOI
The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling
Sarah Baxendale,Claire Davison,Claire Muxworthy,Christian Wolff,Philip W. Ingham,Sudipto Roy,Sudipto Roy +6 more
TL;DR: The gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers, encodes the zebrafish homolog of Blimp-1, a SET domain–containing transcription factor that promotes the terminal differentiation of B lymphocytes in mammals.
Journal ArticleDOI
Comparative sequence analysis of the human and pufferfish Huntington's disease genes.
Sarah Baxendale,Sarah Abdulla,Greg Elgar,David Buck,Mary Berks,Gos Micklem,Richard Durbin,Gill Bates,Sydney Brenner,Stephan Beck,Hans Lehrach +10 more
TL;DR: This work cloned and sequenced the homologue of the HD gene in the pufferfish, Fugu rubripes, and describes a detailed example of sequence comparison between human and Fugu, which illustrates the power of the Pufferfish genome as a model system in the analysis of human genes.