S
Sarah E. Henrickson
Researcher at Children's Hospital of Philadelphia
Publications - 119
Citations - 9296
Sarah E. Henrickson is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 33, co-authored 99 publications receiving 7938 citations. Previous affiliations of Sarah E. Henrickson include University of Würzburg & Harvard University.
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Journal ArticleDOI
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
TL;DR: T-cell priming by DCs occurs in three successive stages: transient serial encounters during the first activation phase are followed by a second phase of stable contacts culminating in cytokine production, which makes a transition into a third phase of high motility and rapid proliferation.
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The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
Andreas Rosenwald,George E. Wright,Adrian Wiestner,Wing C. Chan,Wing C. Chan,Joseph M. Connors,Joseph M. Connors,Elias Campo,Elias Campo,Randy D. Gascoyne,Randy D. Gascoyne,Thomas M. Grogan,Thomas M. Grogan,H. Konrad Muller-Hermelink,H. Konrad Muller-Hermelink,Erlend B. Smeland,Erlend B. Smeland,Michael Chiorazzi,Jena M. Giltnane,Elaine M. Hurt,Hong Zhao,Lauren Averett,Sarah E. Henrickson,Liming Yang,John Powell,Wyndham H. Wilson,Elaine S. Jaffe,Richard M. Simon,Richard D. Klausner,Emilio Montserrat,Emilio Montserrat,Francesc Bosch,Francesc Bosch,Timothy C. Greiner,Dennis D. Weisenburger,Dennis D. Weisenburger,Warren G. Sanger,Bhavana J. Dave,James C. Lynch,James C. Lynch,Julie M. Vose,James O. Armitage,Richard I. Fisher,Richard I. Fisher,Thomas P. Miller,Thomas P. Miller,Michael LeBlanc,Michael LeBlanc,German Ott,German Ott,Stein Kvaløy,Stein Kvaløy,Harald Holte,Harald Holte,Jan Delabie,Jan Delabie,Louis M. Staudt +56 more
TL;DR: A quantitative model of the aberrant cell cycle regulation in MCL is proposed that provides a rationale for the design of cell cycle inhibitor therapy in this malignancy.
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ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
Adrian Wiestner,Andreas Rosenwald,Todd S. Barry,George E. Wright,R. Eric Davis,Sarah E. Henrickson,Hong Zhao,Rachel E. Ibbotson,Jenny A. Orchard,Zadie Davis,Maryalice Stetler-Stevenson,Mark Raffeld,Diane C. Arthur,Gerald E. Marti,Wyndham H. Wilson,Terry J. Hamblin,David Oscier,Louis M. Staudt +17 more
TL;DR: ZAP-70 expression and IgVH mutation status were comparable in their ability to predict time to treatment requirement following diagnosis, and reverse transcriptase-polymerase chain reaction and immunohistochemical assays for ZAP- 70 expression can be applied clinically and would yield important prognostic information for patients with CLL.
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Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
Tobias Junt,E. Ashley Moseman,Matteo Iannacone,Steffen Massberg,Philipp A. Lang,Marianne Boes,Katja Fink,Sarah E. Henrickson,Dmitry M. Shayakhmetov,Nelson C. Di Paolo,Nico van Rooijen,Thorsten R. Mempel,Sean P. J. Whelan,Ulrich H. von Andrian +13 more
TL;DR: Findings indicate that CD169+ macrophages have a dual physiological function that acts as innate ‘flypaper’ by preventing the systemic spread of lymph-borne pathogens and as critical gatekeepers at the lymph–tissue interface that facilitate the recognition of particulate antigens by B cells and initiate humoral immune responses.
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Driven DNA transport into an asymmetric nanometer-scale pore.
TL;DR: To understand the mechanism by which individual DNA molecules enter nanometer-scale pores, it is found that the blockade frequency is proportional to the polymer concentration, that it increases exponentially with the applied potential, and that DNA enters the pore more readily through the entrance that has the larger vestibule.