Sarah Ehses

TL;DR: It is reported that mitochondria hyperfuse and form a highly interconnected network in cells exposed to selective stresses and represents a novel adaptive pro‐survival response against stress.

TL;DR: The cleavage by OMA1 causes an accumulation of the short OPA1 variants, and the role ofm-AAA proteases in ensuring a balance of long and short Opa1 isoforms is investigated.

TL;DR: A regulatory role of an AAA protease for mitochondrial protein synthesis in yeast is described and mitochondrial defects associated with m-AAA protease mutants in yeast are rationalize and shed new light on the mechanism of axonal degeneration in HSP.

TL;DR: It is established that mammalian m-AAA proteases can act as processing enzymes in vivo and overlapping activities of Afg3l1 and Afg 3l2 are revealed, of relevance for the pathogenesis of neurodegenerative disorders associated with mutations in different m- AAA protease subunits.

TL;DR: It is demonstrated that the biogenesis of functional TAP depends on the assembly of preexisting TAP1 with newly synthesised TAP2, but not vice versa, and proposed that the observed assembly mechanism of TAP protects newly synthesized TAP 2 from rapid degradation and controls the number of transport active transporter molecules.