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Sarah J. Neal
Researcher at Pfizer
Publications - 11
Citations - 915
Sarah J. Neal is an academic researcher from Pfizer. The author has contributed to research in topics: Receptor & Allosteric modulator. The author has an hindex of 9, co-authored 11 publications receiving 815 citations. Previous affiliations of Sarah J. Neal include Novartis & Princeton University.
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Journal ArticleDOI
Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes.
Stacey J. Sukoff Rizzo,Stacey J. Sukoff Rizzo,Sarah J. Neal,Zoë A. Hughes,Mercedes Beyna,Sharon Rosenzweig-Lipson,Stephen J. Moss,Stephen J. Moss,Nicholas J. Brandon,Nicholas J. Brandon +9 more
TL;DR: Elevations in IL-6 may have a pathophysiological role underlying depression and more specifically resistance to current classes of antidepressant medications and modulation of the IL- 6 signaling pathway may have therapeutic potential for treatment-resistant depression.
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Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders.
Sarah K. Leonard,Jason M. Dwyer,Stacey J. Sukoff Rizzo,Brian J. Platt,Sheree F. Logue,Sarah J. Neal,Jessica E. Malberg,Chad E. Beyer,Lee E. Schechter,Sharon Rosenzweig-Lipson,Robert H. Ring +10 more
TL;DR: These data provide an important confirmation and expansion of the anxiolytic-like effects of NPS and implicate the NPS system as a novel target for anxIOlytic drug discovery.
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CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency
Michael Bidinosti,Paolo Botta,Sebastian Krüttner,Catia C. Proenca,Natacha Stoehr,Mario Bernhard,Isabelle Fruh,Matthias Mueller,Debora Bonenfant,Hans Voshol,Walter Carbone,Sarah J. Neal,Stephanie M. McTighe,Guglielmo Roma,Ricardo E. Dolmetsch,Jeffrey A. Porter,Pico Caroni,Tewis Bouwmeester,Andreas Lüthi,Ivan Galimberti +19 more
TL;DR: This study provides a novel mechanistic and potentially therapeutic understanding of deregulated signaling downstream of Shank3 deficiency, and uses unbiased, quantitative proteomics to identify changes in the phosphoproteome of Shank2-deficient neurons.
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The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex
TL;DR: BTBR mice have attentional impairments and alterations in a key neural substrate of attention, and it is proposed that they may be valuable for studying mechanisms for treatment of cognitive dysfunction in individuals with attention deficits and autism.
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The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise?
Stacey J. Sukoff Rizzo,Sarah K. Leonard,Adam M. Gilbert,Paul Jeffrey Dollings,Deborah L. Smith,Meiyi Zhang,Li Di,Brian J. Platt,Sarah J. Neal,Jason M. Dwyer,Corey N. Bender,Jean Zhang,Tim Lock,Dianne Kowal,Angela Kramer,Andrew D. Randall,Christine Huselton,Karthick Vishwanathan,Susanna Y. Tse,John A. Butera,Robert H. Ring,Sharon Rosenzweig-Lipson,Zoë A. Hughes,John Dunlop +23 more
TL;DR: The reported in vivo actions of AMN082 should be interpreted with caution, because they may involve other mechanisms in addition to mGluR7.