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Sarah K. Kummerfeld
Researcher at Garvan Institute of Medical Research
Publications - 43
Citations - 12412
Sarah K. Kummerfeld is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 24, co-authored 43 publications receiving 10610 citations. Previous affiliations of Sarah K. Kummerfeld include Medical Research Council & University of Sydney.
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Journal ArticleDOI
The Transcriptional Landscape of the Mammalian Genome
Piero Carninci,Takeya Kasukawa,Shintaro Katayama,Julian Gough,Martin C. Frith,N. Maeda,Rieko Oyama,Timothy Ravasi,Boris Lenhard,Christine A. Wells,Christine A. Wells,Rimantas Kodzius,Kazuro Shimokawa,Vladimir B. Bajic,Steven E. Brenner,Serge Batalov,Alistair R. R. Forrest,Mihaela Zavolan,Melissa J. Davis,Laurens G. Wilming,Vassilis Aidinis,Jonathan E. Allen,Alberto Ambesi-Impiombato,Rolf Apweiler,Rajith N. Aturaliya,Timothy L. Bailey,Mukesh Bansal,Laura L. Baxter,Kirk W. Beisel,T. Bersano,Hidemasa Bono,Alistair M. Chalk,Kuo Ping Chiu,V. Choudhary,Alan Christoffels,D. R. Clutterbuck,Mark L. Crowe,Emiliano Dalla,Brian P. Dalrymple,Bernard de Bono,G. Della Gatta,Diego di Bernardo,Thomas A. Down,Pär G. Engström,Michela Fagiolini,Geoffrey J. Faulkner,Colin F. Fletcher,T. Fukushima,Masaaki Furuno,Sugiko Futaki,Manuela Gariboldi,P. Georgii-Hemming,Thomas R. Gingeras,Takashi Gojobori,Richard E. Green,Stefano Gustincich,Matthias Harbers,Yoshitaka Hayashi,Takao K. Hensch,Nobutaka Hirokawa,David E. Hill,Lukasz Huminiecki,M. Iacono,Kazuho Ikeo,Atsushi Iwama,T. Ishikawa,M. Jakt,Alexander Kanapin,Masaru Katoh,Yuka Imamura Kawasawa,Janet Kelso,Hiroshi Kitamura,Hiroaki Kitano,George Kollias,S. P. T. Krishnan,Adele Kruger,Sarah K. Kummerfeld,Igor V. Kurochkin,Liana F. Lareau,Dejan Lazarevic,Leonard Lipovich,Jinfeng Liu,Sabino Liuni,Sean McWilliam,M. Madan Babu,Martin Madera,Luigi Marchionni,Hideo Matsuda,Shu-ichi Matsuzawa,Harukata Miki,Flavio Mignone,Sou Miyake,Ken A. Morris,Salim Mottagui-Tabar,Salim Mottagui-Tabar,Nicola Mulder,Naoko Nakano,Hiromitsu Nakauchi,P. Ng,Roland Nilsson,S. Nishiguchi,Seishi Nishikawa,Franco Nori,Osamu Ohara,Yasushi Okazaki,Valerio Orlando,Ken C Pang,William J. Pavan,Giulio Pavesi,Graziano Pesole,Nikolai Petrovsky,Silvano Piazza,Jonathan C. Reed,James F. Reid,Brian Z. Ring,M. Ringwald,Burkhard Rost,Yijun Ruan,Steven L. Salzberg,Albin Sandelin,Claudio Schneider,Christian Schönbach,K. Sekiguchi,Colin A. Semple,Shigeto Seno,Luca Sessa,Y. Sheng,Y. Shibata,Hiroshi Shimada,Kiyo Shimada,D. Silva,B. Sinclair,Silke Sperling,Elia Stupka,Koji Sugiura,Razvan Sultana,Yoichi Takenaka,Kohei Taki,K. Tammoja,Sin Lam Tan,S. Tang,Martin S. Taylor,Jesper Tegnér,Sarah A. Teichmann,Hiroki R. Ueda,Erik van Nimwegen,Roberto Verardo,Chia-Lin Wei,Ken Yagi,H. Yamanishi,E. Zabarovsky,S. Zhu,Andreas Zimmer,Winston Hide,Carol J. Bult,Sean M. Grimmond,Rohan D. Teasdale,Edison T. Liu,Vladimir Brusic,John Quackenbush,Claes Wahlestedt,Claes Wahlestedt,John S. Mattick,David A. Hume,C. Kai,D. Sasaki,Yasuhiro Tomaru,S. Fukuda,Mutsumi Kanamori-Katayama,M. Suzuki,Junken Aoki,Taku Arakawa,J. Iida,Kengo Imamura,Masayoshi Itoh,T. Kato,Hideya Kawaji,N. Kawagashira,Tsugumi Kawashima,M. Kojima,S. Kondo,Hideaki Konno,K. Nakano,Noriko Ninomiya,T. Nishio,M. Okada,Charles Plessy,K. Shibata,Toshiyuki Shiraki,S. Suzuki,Michihira Tagami,Kazunori Waki,Akira Watahiki,Yuko Okamura-Oho,Harukazu Suzuki,Jun Kawai,Yoshihide Hayashizaki,Yoshihide Hayashizaki +197 more
TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
Journal ArticleDOI
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
Journal ArticleDOI
A census of human transcription factors: function, expression and evolution
Juan M. Vaquerizas,Sarah K. Kummerfeld,Sarah K. Kummerfeld,Sarah A. Teichmann,Nicholas M. Luscombe,Nicholas M. Luscombe +5 more
TL;DR: An analysis of 1,391 manually curated sequence-specific DNA-binding transcription factors, their functions, genomic organization and evolutionary conservation provides a solid foundation for future investigations to elucidate regulatory mechanisms underlying diverse mammalian biological processes.
Journal ArticleDOI
The genome of the social amoeba Dictyostelium discoideum
Ludwig Eichinger,Justin A. Pachebat,Justin A. Pachebat,Gernot Glöckner,Marie-Adèle Rajandream,Richard Sucgang,Matthew Berriman,J. Song,Rolf Olsen,Karol Szafranski,Qikai Xu,Budi Tunggal,Sarah K. Kummerfeld,Martin Madera,Bernard Anri Konfortov,Francisco Rivero,Alan T. Bankier,Rüdiger Lehmann,N. Hamlin,Robert L. Davies,Pascale Gaudet,Petra Fey,Karen E Pilcher,Guokai Chen,David L. Saunders,Erica Sodergren,P. Davis,Arnaud Kerhornou,X. Nie,Neil Hall,Christophe Anjard,Lisa Hemphill,Nathalie Bason,Patrick Farbrother,Brian A. Desany,Eric M. Just,Takahiro Morio,René Rost,Carol Churcher,J. Cooper,Stephen F. Haydock,N. van Driessche,Ann Cronin,Ian Goodhead,Donna M. Muzny,T. Mourier,Arnab Pain,Mingyang Lu,D. Harper,R. Lindsay,Heidi Hauser,Kylie R. James,M. Quiles,M. Madan Babu,Tsuneyuki Saito,Carmen Buchrieser,A. Wardroper,A. Wardroper,Marius Felder,M. Thangavelu,D. Johnson,Andrew J Knights,H. Loulseged,Karen Mungall,Karen Oliver,Claire Price,Michael A. Quail,Hideko Urushihara,Judith Hernandez,Ester Rabbinowitsch,David Steffen,Mandy Sanders,Jun Ma,Yuji Kohara,Sarah Sharp,Mark Simmonds,S. Spiegler,Adrian Tivey,Sumio Sugano,Brian White,Danielle Walker,John Woodward,Thomas Winckler,Yoshiaki Tanaka,Gad Shaulsky,Michael Schleicher,George M. Weinstock,André Rosenthal,Edward C. Cox,Rex L. Chisholm,Richard A. Gibbs,William F. Loomis,Matthias Platzer,Robert R. Kay,Jeffrey G. Williams,Paul H. Dear,Angelika A. Noegel,Bart Barrell,Adam Kuspa +98 more
TL;DR: A proteome-based phylogeny shows that the amoebozoa diverged from the animal–fungal lineage after the plant–animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.
Journal ArticleDOI
Comparative genomics of trypanosomatid parasitic protozoa.
Najib M. El-Sayed,Peter J. Myler,Peter J. Myler,Gaëlle Blandin,Matthew Berriman,Jonathan Crabtree,Gautam Aggarwal,Elisabet Caler,Hubert Renauld,Elizabeth A. Worthey,Christiane Hertz-Fowler,Elodie Ghedin,Christopher S. Peacock,Daniella Castanheira Bartholomeu,Brian J. Haas,Anh Nhi Tran,Jennifer R. Wortman,U. Cecilia M. Alsmark,Samuel V. Angiuoli,Atashi Anupama,Jonathan H. Badger,Frédéric Bringaud,Eithon Cadag,Jane M. Carlton,Gustavo C. Cerqueira,Todd Creasy,Arthur L. Delcher,Appolinaire Djikeng,T. Martin Embley,Christopher R. Hauser,Alasdair Ivens,Sarah K. Kummerfeld,José B. Pereira-Leal,Daniel Nilsson,Jeremy Peterson,Steven L. Salzberg,Joshua Shallom,Joana C. Silva,Jaideep P. Sundaram,Scott J. Westenberger,Owen White,Sara E. Melville,John E. Donelson,Björn Andersson,Kenneth Stuart,Kenneth Stuart,Neil Hall +46 more
TL;DR: No evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont is revealed, and a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters is revealed.