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Sarah Kandil
Researcher at Imperial College London
Publications - 1
Citations - 61
Sarah Kandil is an academic researcher from Imperial College London. The author has contributed to research in topics: Cancer epigenetics & Chromatin immunoprecipitation. The author has an hindex of 1, co-authored 1 publications receiving 40 citations.
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Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
Edward Curry,Ian Green,Nadine Chapman-Rothe,Elham Shamsaei,Sarah Kandil,Fanny L. Cherblanc,Luke Payne,Emma Bell,Thota Ganesh,Nitipol Srimongkolpithak,Joachim Caron,Fengling Li,Anthony G. Uren,James P. Snyder,Masoud Vedadi,Matthew J. Fuchter,Robert S. Brown +16 more
TL;DR: It is demonstrated that dual inhibition of EZH2 and EHMT2 is more effective at eliciting biological responses of gene transcription and cancer cell growth inhibition compared to inhibition of single HKMTs, and the first dual EZh2-EHMT1/2 substrate competitive inhibitors that are functional in cells are reported.