Sardana Satish

Bio: Sardana Satish is an academic researcher from Hindu College, University of Delhi. The author has contributed to research in topics: Wound healing & Context (language use). The author has an hindex of 4, co-authored 5 publications receiving 79 citations.

Herbal boon for wounds

Abstract: Wounds are simply defined as the disruption of cellular and anatomic continuity of a tissue. These are prime cause for physical disabilities. Plants and their extracts have a tremendous potential in the management and treatment of wounds. The phyto-medicines for wound healing are not only cheap and cost-effective but also reportedly safe as compared to allopathic drugs in context of hypersensitive reactions. The presence of various life sustaining constituents in the plants has also urged scientist to examine these plants with a view to determine their potentiating wound healing properties. Worldwide, there is an immense need for the collection of ethno-botanical data regarding wound healing activity. The present review is a sincere attempt to analyze and compile various pharmacological reports of Indian medicinal plants employed in wound healing.

Evaluation of wound healing, antioxidant and antimicrobial efficacy of jasminum auriculatum vahl. leaves

Abstract: Objective: To validate the ethno-therapeutic claim of the traditionally used plant Jasminum auriculatum (J. auriculatum) in skin diseases, by evaluating its wound healing potential along with its antioxidant and antimicrobial properties; so as to understand their role in wound healing. Materials and Methods: Excision and incision wound models were used to evaluate the wound healing activity on albino rats. The wound healing potential was assessed by measuring rate of wound contraction, epithelialization period, hydroxyproline content, skin breaking strength and histopathological parameters. Reference standard drug was Nitrofurazone ointment. The antioxidant activity was determined using 2, 2-diphenyl-1picrylhydrazyl (DPPH) method. The antimicrobial activity was determined by agar well diffusion method and minimum inhibitory concentration by serial dilution method. Results: Higher rate of wound contraction (83.66±0.50% on 15th day), decrease in the period of epithelialization (17.83±1.6days), higher skin breaking strength (170.71±1.52g), higher collagen content and favourable histopathological changes revealed that topical application of ointment containing successive ethanolic extract (S.E.E) of J. auriculatum leaves has the most potent wound healing ability compared to control group in both the models studied. The DPPH radical scavenging activity of successive ethanolic extract was found to be 33.39µg/ml. Successive ethanolic extract was found to be most effective against Pseudomonas auregenosa having a zone of inhibition 16.65±0.6mm and the minimum inhibitory concentration was 0.78mg/ml. Conclusion: The data of this study indicate that successive ethanolic extract of the leaves exhibit potent wound healing, antioxidant and antimicrobial properties. This justifies the ethnomedicinal use of plant for the treatment of wound and microbial infections.

Phytopharmacological Profile of Jasminum grandiflorum Linn. (Oleaceae)

Abstract: Plants are the real basis towards animal life and are also central to people's livelihood. The contributions of the plants in performing varied religious celebrations and in other multiple beneficiaries like medicine, human happiness as well as in treating deadly diseases can never be neglected. In treating diseases, the plants and their constituents are better choice than any other synthetic chemical. The nature has been kind enough to provide the human beings with various types of medicinal plants and in the real sense these form the storehouse of curing almost all the ailments. Consequently, most of the drugs which are being used in preparing formulations have their origin and roots in the plants which form the chief natural source of medicines. Even in modern era, the plant-derived drugs are being extensively used, either in their original or semi-synthetic form. It is because their natural phytoconstituents are highly innocuous posing relatively fewer or no side effects. Based upon their observations, analysis and experience, our ancestors used many plants for medicinal purposes and thus their efforts need to be supported by scientific evidence. Jasminum grandiflorum Linn. is one of such important plants. It has been extensively used by the tribes all over India to treat different diseases which mainly include body pains, toothache, stomach ache, ulcers, and sexual impotency. Chemistry of the plant revealed the presence of mainly secoiridoids, terpenoids, flavonoids and tannins. Not much scientific support was given to the folklore claims for this plant but some of its traditional uses were investigated like spasmolytic, wound healing, antimicrobial, angiotensin converting enzyme inhibitor, antiulcer and antioxidant activities. This article is the review of research works done on the plant Jasminum grandiflorum Linn. to date. As a part of it the local names, morphology, traditional claims, chemistry and pharmacological activities have been discussed.

Experimental wound healing aspects of Jasminum grandiflorum Linn: a preclinical study

Abstract: Background: Jasminum grandiflorum is an important shrub of family Oleaceae and ancient literature mentions its various medicinal uses especially its efficacy in wound healing. To substantiate its traditional claim the present study was conceived. Materials and Methods: Preliminary wound healing activity of successive extracts of leaves was assessed by measuring wound contraction using excision wound model and the detailed study of most potent extract was evaluated by measuring wound contraction, epithelialization period, hydroxyproline content, tissue breaking strength and histopathology parameters by excision and incision wound models. The antioxidant activity was determined by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. The agar well-diffusion method and minimum inhibitory concentration (MIC) was used to established antimicrobial efficacy. Results: The results show that successive ethanolic extract of the leaves exhibited promising wound healing, antioxidant and antimicrobial properties. Conclusion: From results; it is concluded that its traditional use for the treatment of wound and in microbial infection is justified.

Phytopharmacological Profi le of Jasminum Grandifl orum Linn. (Oleaceae)

Abstract: Plants are the real basis towards animal life and are also central to people's livelihood. The Plants are the real basis towards animal life and are also central to people's livelihood. The contributions of the plants in performing varied religious celebrations and in other multiple beneficiaries like contributions of the plants in performing varied religious celebrations and in other multiple beneficiaries like medicine, human happiness as well as in treating deadly diseases can never be neglected. In treating diseases, medicine, human happiness as well as in treating deadly diseases can never be neglected. In treating diseases, the plants and their constituents are better choice than any other synthetic chemical. The nature has been kind the plants and their constituents are better choice than any other synthetic chemical. The nature has been kind enough to provide the human beings with various types of medicinal plants and in the real sense these form the enough to provide the human beings with various types of medicinal plants and in the real sense these form the storehouse of curing almost all the ailments. Consequently, most of the drugs which are being used in preparing storehouse of curing almost all the ailments. Consequently, most of the drugs which are being used in preparing formulations have their origin and roots in the plants which form the chief natural source of medicines. Even in formulations have their origin and roots in the plants which form the chief natural source of medicines. Even in modern era, the plant-derived drugs are being extensively used, either in their original or semi-synthetic form. It modern era, the plant-derived drugs are being extensively used, either in their original or semi-synthetic form. It is because their natural phytoconstituents are highly innocuous posing relatively fewer or no side effects. Based is because their natural phytoconstituents are highly innocuous posing relatively fewer or no side effects. Based upon their observations, analysis and experience, our ancestors used many plants for medicinal purposes upon their observations, analysis and experience, our ancestors used many plants for medicinal purposes and thus their efforts need to be supported by scientifi c evidence. and thus their efforts need to be supported by scientifi c evidence. Jasminum grandifl orum Jasminum grandifl orum Linn. is one of such Linn. is one of such important plants. It has been extensively used by the tribes all over India to treat different diseases which mainly important plants. It has been extensively used by the tribes all over India to treat different diseases which mainly include body pains, toothache, stomach ache, ulcers, and sexual impotency. Chemistry of the plant revealed the include body pains, toothache, stomach ache, ulcers, and sexual impotency. Chemistry of the plant revealed the presence of mainly secoiridoids, terpenoids, fl avonoids and tannins. Not much scientifi c support was given to the presence of mainly secoiridoids, terpenoids, fl avonoids and tannins. Not much scientifi c support was given to the folklore claims for this plant but some of its traditional uses were investigated like spasmolytic, wound healing, folklore claims for this plant but some of its traditional uses were investigated like spasmolytic, wound healing, antimicrobial, angiotensin converting enzyme inhibitor, antiulcer and antioxidant activities. This article is the antimicrobial, angiotensin converting enzyme inhibitor, antiulcer and antioxidant activities. This article is the review of research works done on the plant review of research works done on the plant Jasminum grandifl orum Jasminum grandifl orum Linn. to date. As a part of it the local names, Linn. to date. As a part of it the local names, morphology, traditional claims, chemistry and pharmacological activities have been discussed. morphology, traditional claims, chemistry and pharmacological activities have been discussed.

Comparative Study on the Antibacterial Activity of Phytochemical Flavanones against Methicillin-resistant Staphylococcus aureus.

Abstract: Differently substituted flavanones were isolated from Leguminosae and their antibacterial activity was comparatively studied against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MICs) of phytochemical flavanones to clinical isolates of MRSA were determined by a serial agar dilution method. The structure-activity relationship has indicated that 2',4'- or 2',6'-dihydroxylation of the B ring and 5,7-dihydroxylation of the A ring in the flavanone structure are important for significant anti-MRSA activity and that substitution with a certain aliphatic group at the 6- or 8-position also enhances the activity. Among the thirteen flavanones tested, tetrahydroxyflavanones with these structural characteristics isolated from Sophora exigua and Echinosophora koreensis showed intensive activity to inhibit the growth of all MRSA strains at 3.13-6.25 micrograms/ml. The present hydroxyflavanones would be useful in the phytotherapeutic strategy against MRSA infections.

Antimicrobial and Wound Healing Properties of Polyacrylonitrile-Moringa Extract Nanofibers

Abstract: A simple and cost-effective material composed of polyacrylonitrile nanofibers containing different concentrations of moringa (MR) leaf extracts was fabricated for antimicrobial properties and wound dressing. The fabricated materials were characterized by scanning electron microscopy, thermal gravimetric analysis, and Fourier transmission infrared spectroscopy. The antibacterial sensitivity of the developed polyacrylonitrile-moringa extract nanofibers was evaluated against Staphylococcus aureus and Escherichia coli by the agar diffusion method. A pronounced antibacterial activity was observed with the increase in the incorporated moringa leaf extract concentration within the polyacrylonitrile-moringa extract nanofibers against the bacterial strains. The best antibacterial sensitivity was observed for nanofibers containing 0.5 g of moringa leaf extract which had an inhibitory zone of 15 mm for E. coli and 12 mm for S. aureus. Furthermore, the cost-effective and biodegradable nanofibrous polyacrylonitrile–mo...

The Effectiveness of Aromatherapy in the Management of Labor Pain and Anxiety: A Systematic Review.

Abstract: BACKGROUND: Aromatherapy as an alternative and complementary medicine is a well-known method for reducing the symptoms of various physiological processes such as labor experience. The aim of this study was to systematically review the currently available evidences evaluating the use of aromatherapy for management of labor pain and anxiety.METHODS: In a systematic review, 5 databases (PubMed, SCOPUS, Web of Science, Google Scholar and Scientific Information Database [SID])were searched, from database inception up to December 2019.Keywords used included (aromatherapy OR "“essential oil” OR "aroma*") AND (pain OR anxiety) AND (laborOR delivery). Using the Cochrane Collaboration's 'Risk of bias' method; the risk of bias in the included studies was evaluated.RESULTS: A total of 33 studies were verified to meet our inclusion criteria. Most of the included studies wereconducted in Iran. Aromatherapy was applied using inhalation, massage, footbath, birthing pool, acupressure, and compress. The most popularly used essential oil in the studies was lavender (13 studies), either as a single essential oil or in a combination with other essential oils. Most of included studies confirmed the positive effect of aromatherapy in reducing labor pain and anxiety.CONCLUSION: The evidences from this study suggest that aromatherapy, as a complementary and alternative modality, can help in relieving maternal anxiety and pain during labor.