Author
Sarder N. Newaz
Bio: Sarder N. Newaz is an academic researcher from Stevens Institute of Technology. The author has contributed to research in topics: Lactam & Thienamycin. The author has an hindex of 4, co-authored 6 publications receiving 226 citations.
Topics: Lactam, Thienamycin, Catalysis, Side chain, Bicyclic molecule
Papers
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175 citations
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TL;DR: A simplified and stereocontrolled synthesis of α-vinyl and α-alkyl β-lactams has been achieved in open vessels under microwave irradiation in unmodified domestic microwave ovens as discussed by the authors.
33 citations
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12 citations
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7 citations
Cited by
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1,321 citations
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TL;DR: In this paper, the authors discuss the conflicting results reported in the literature on the effect of microwave radiation on the dielectric heating of materials, and show that microwave radiation has a clear reaction rate enhancement compared to the thermal method under similar reaction conditions and temperatures indicating a "microwave specific effect".
Abstract: Industrial use of microwave radiation as an alternative to conventional thermal heating has generated interest recently mainly because of the drastic reduction in the processing time. In spite of its wide application, its chemical mechanism of interaction with materials has not been well understood. The current debate on the alternative use of microwave radiation to conventional thermal heating is on the involvement of a “microwave specific effect” other than the well accepted dielectric heating. There are reports of various reactions which show similar kinetics under both microwave and thermal methods at similar temperatures suggesting simple dielectric heating of materials by microwaves. There are also reports which show a clear reaction rate enhancement under microwave radiation compared to the thermal method under similar reaction conditions and temperatures indicating a “microwave specific effect” other than the simple dielectric heating of materials. This paper will discuss the above conflicting results reported in the literature.
267 citations
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TL;DR: Microwave irradiation has been applied with success to cycloaddition reactions as mentioned in this paper, and the results of these reactions usually require long reaction times, high temperatures, and/or Lewis acid catalysts, resulting in partial or total decomposition of sensitive compounds.
160 citations
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TL;DR: In this article, an inclusion complex of beta-cyclodextrin with carvedilol was prepared by using a convenient new method of microwave irradiation, and the structure of inclusion complex was determined by fluorescence spectroscopy and 1H NMR, 13C NMR measurements in solution.
148 citations
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TL;DR: In this paper, the authors used microwave irradiation in open vessels using high-boiling solvents such as ethylene glycol (bp 198 °C) as the microwave energy transfer agent to reduce double bonds and hydrogenolysis of several functional groups.
Abstract: Catalytic transfer hydrogenation has been conducted under microwave irradiation in open vessels using high-boiling solvents such as ethylene glycol (bp 198 °C) as the microwave energy transfer agent Reduction of double bonds and hydrogenolysis of several functional groups were carried out safely and rapidly (3−5 min) at about 110−130 °C with 10% Pd/C as an efficient catalyst and ammonium formate as the hydrogen donor Diverse types of β-lactam synthons were prepared by the reduction of ring substituents containing alkene and alkylidene groups or conjugated unsaturated esters Cleavage of the β-lactam ring by hydrogenolysis of the N−C4 bond of 4-aryl-2-azetidinones was a facile reaction with 10% Pd/C as the catalyst; but no ring scission occurred when Raney nickel catalyst was employed Dehalogenation of aromatic compounds was also successful with ammonium formate and Pd/C catalyst Hydrogenolysis of phenylhydrazone of methyl benzoylformate gave the methyl ester of phenylglycine in excellent yield The te
140 citations