Sarjit Singh Sandhu

Bio: Sarjit Singh Sandhu is an academic researcher from Guru Nanak Dev University. The author has contributed to research in topics: Arsine & Phosphine. The author has an hindex of 7, co-authored 45 publications receiving 236 citations.

Synthesis, spectroscopic, and magnetic studies of copper(II) with N-protected amino acids: crystal and molecular structure of diaquatetrakis(µ-N-benzoyl-α-alaninato)-dicopper(II)

Abstract: Eighteen complexes of copper(II) having the general formula CuL2·nH2O (n= 1–4) with N-protected amino acids (HL) have been prepared and characterized by spectroscopic methods and magnetic susceptibility measurements. These complexes belong to three types: binuclear species having bridging bidentate co-ordination through the carboxylate group, mononuclear species having symmetrical chelating bidentate co-ordination or bridging bidentate co-ordination with no Cu–Cu interaction, and mononuclear species having highly unsymmetrical chelating bidentate or non-chelating unidentate co-ordination through the carboxylate group. The complex [{Cu(Bz-α-AlaO)2(H2O)}2] crystallizes in the triclinic system with space group P, and unit-ceil parameters a= 9.421 (2), b= 9.549(2), c= 12.618(3)A,α= 74.31(2), β= 79.21(2), γ= 88.69(2)°, and Z= 1. Full-matrix least-squares refinement using 2 842 independent reflections converged to a final R= 0.038 and R′= 0.052. The complex has a typical copper(II) acetate monohydrate type structure with mean Cu–O(carboxylate), Cu–O(water), and Cu–Cu distances of 1.968(3), 2.138(4), and 2.664(1)A, respectively.

Synthesis, characteristic spectral studies and in vitro antimicrobial and antitumour activities of organotin(IV) complexes of Schiff bases derived from amino-acids

Abstract: Equimolar reactions of dibutyltin(IV) oxide with Schiff bases derived from amino-acids led to the formation of a new series of dibutyltin(IV) complexes of general formula, Bu2SnL [L=dianion of tridentate Schiff bases derived from the condensation of 2-hydroxy-1-naphthaldehyde or acetyl acetone with glycine (L-1), L-β-alanine (L-2), DL-valine (L-3), DL-4-aminobutyric acid (L-4), L-methionine (L-5), L-leucine (L-6) and phenylglycine (L-7)]. An attempt has been made to prove the structures of the resulting complexes on the basis of elemental analyses, conductance measurements and electronic, IR, multinuclear magnetic resonance (1H, 13C and 117Sn) and 119Sn Mossbauer spectral studies. The complexes have been tested against various bacteria [Streptococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus penicillin resistance (2500 units)] and fungi (Candida albicans, Cryptococcus neoformans, Sporotrichum schenckii,Trichophyton mentagrophytes and Aspergillus fumigatus). All the complexes showed moderate activity. The cytotoxicity of a few compounds has been screened in vitro against seven human tumour cell lines, viz. MCF-7, EVSA-T, WiDr, IGROV, M19 MEL, A498 and H226. The activities found experimentally were better than those obtained for cisplatin and carboplatin © 1997 John Wiley & Sons, Ltd.