S
Sarka Tumova
Researcher at University of Leeds
Publications - 45
Citations - 3045
Sarka Tumova is an academic researcher from University of Leeds. The author has contributed to research in topics: Heparan sulfate & Glucose transporter. The author has an hindex of 22, co-authored 41 publications receiving 2619 citations. Previous affiliations of Sarka Tumova include University of Missouri–Kansas City & Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
Piezo1 integration of vascular architecture with physiological force
Jing Li,Bing Hou,Sarka Tumova,Katsuhiko Muraki,Alexander F. Bruns,Melanie J. Ludlow,Alicia Sedo,Adam J. Hyman,Lynn McKeown,Richard S. Young,Richard S. Young,Nadira Yuldasheva,Yasser Majeed,Lesley A. Wilson,Baptiste Rode,Marc A. Bailey,Hyejeong R. Kim,Zhaojun Fu,Deborah Angela Louise Carter,Jan Bilton,Helen Imrie,Paul Ajuh,T. Neil Dear,Richard M Cubbon,Mark T. Kearney,K. Raj Prasad,Paul C. Evans,Justin F. X. Ainscough,David J. Beech +28 more
TL;DR: Piezo1 channels are shown as sensors of frictional force (shear stress) and determinants of vascular structure in both development and adult physiology and the data suggest that Piezo 1 channels function as pivotal integrators in vascular biology.
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Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions.
TL;DR: This review concentrates on biological roles of cell surface heparan sulfate proteoglycans, namely syndecans and glypicans, and outlines the progress achieved during the last decade in unraveling the molecular interactions behind proteoglycan functions.
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Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts.
TL;DR: It is reported that the glycosaminoglycan chains of syndecan-4 bind recombinant HepII and it is incorporated into forming focal adhesions.
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Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)
TL;DR: HMGB1 polypeptide has a weak proinflammatory activity by itself, and it binds to bacterial substances, including lipids, that may strengthen its effects.
Journal ArticleDOI
Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin.
Maxim M. Bespalov,Yulia Sidorova,Sarka Tumova,Anni Ahonen-Bishopp,Ana Cathia Magalhães,Evgeny Kulesskiy,Mikhail Paveliev,Claudio Rivera,Heikki Rauvala,Mart Saarma +9 more
TL;DR: Syndecan-3 may act alone or as a coreceptor with RET to promote cell spreading, neurite outgrowth, and migration of cortical neurons by GNDF, NRTN, and ARTN.