S
Sarthak Sahoo
Researcher at Indian Institute of Science
Publications - 40
Citations - 348
Sarthak Sahoo is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 7, co-authored 24 publications receiving 124 citations.
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Journal ArticleDOI
A Computational Systems Biology Approach Identifies SLUG as a Mediator of Partial Epithelial-Mesenchymal Transition (EMT).
TL;DR: In this paper, an EMT-inducing transcription factor, SLUG (SNAIL2), was shown to stabilize hybrid E/M phenotypes in a computational system biology approach.
Journal ArticleDOI
Multi-stability in cellular differentiation enabled by a network of three mutually repressing master regulators.
TL;DR: The dynamics of three master regulators A, B and C inhibiting each other are investigated, thus forming three-coupled toggle switches to form a toggle triad that can lead to co-existence of cells into three differentiated ‘single positive' phenotypes.
Journal ArticleDOI
A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells.
Sarthak Sahoo,Ashutosh Mishra,Harsimran Kaur,Kishore Hari,Srinath Muralidharan,Susmita Mandal,Mohit Kumar Jolly +6 more
TL;DR: In this article, the authors investigated coupled dynamics of epithelial-mesenchymal transition (EMT) in breast cancer cells and emergence of reversible drug resistance and proposed the potential therapeutic use of mesenchym-epithelial transition inducers besides canonical anti-estrogen therapy to limit the emergence of drug resistance.
Posted ContentDOI
A computational systems biology approach identifies SLUG as a mediator of partial Epithelial-Mesenchymal Transition (EMT)
TL;DR: It is demonstrated that SLUG (SNAIL2) – an EMT-inducing transcription factor – can inhibit cells from undergoing a complete EMT and thus stabilizing them in hybrid E/M phenotype, thereby behaving as a phenotypic stability factor (PSF).
Journal ArticleDOI
Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor.
Anumeha Singh,Lekha E. Manjunath,Pradipta Kundu,Sarthak Sahoo,Arpan Das,Harikumar R Suma,Paul L. Fox,Sandeep M. Eswarappa +7 more
TL;DR: Overall, the results reveal a negative feedback loop in the mi RNA pathway mediated by the translational readthrough product of AGO1, which can serve as a competitive inhibitor of miRNA pathway.