Author
Saša Baumgartner
Bio: Saša Baumgartner is an academic researcher from University of Ljubljana. The author has contributed to research in topics: Nanofiber & Electrospinning. The author has an hindex of 22, co-authored 42 publications receiving 2296 citations.
Papers
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TL;DR: The investigation shows that tablet composition and mechanical strength have the greatest influence on the floating properties and drug release of the floating matrix tablets after oral administration.
386 citations
TL;DR: The formulation of ibuprofen as a nanosuspension, either in the form of lyophilized powder or granules, was very successful in enhancing dissolution rate, and the increase in in vitro dissolution rate may favourably affect bioavailability and improve safety for the patient by decreasing gastric irritancy.
370 citations
TL;DR: The mechanism of RH impact on the electrospinning process is addressed and the background to exploit it in order to better control nanomaterial properties and alter its applicability is offered.
214 citations
TL;DR: This study examines the critical issues regarding engineering of a nanosuspension tailored to increase drug dissolution rate and its transformation into dry powder suitable for tabletting to achieve controlled crystallization and size.
176 citations
TL;DR: In this paper, a thorough rheological study of polymer solutions in the bulk and at the interface was conducted to find correlations between those properties and the electrospinnability of the solutions and the morphology of the resultant nanofibers.
136 citations
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TL;DR: In this paper, the authors provide an overview of the electrospinning (applied electric field, distance between the needle and collector and flow rate, needle diameter), solution (polymer concentration, viscosity, solvent and solution conductivity) and environmental (relativity humidity and temperature) parameters that affect the nanofibers fabrication.
1,071 citations
TL;DR: The principles behind nanosizing, the production and characterization of nanoformulations as well as the current experience with utilization of such formulations in vivo are described.
967 citations
TL;DR: In this article, the authors reviewed several novel examples of pharmaceutical cocrystals from the past decade and analyzed the enhanced solubility profiles of cocrystal profiles, showing that the peak dissolution for pharmaceutical cocystals occurs in a short time (<30 min), and high-solubility is maintained over a sufficiently long period (4-6 h) for the best cases.
Abstract: The current phase of drug development is witnessing an oncoming crisis due to the combined effects of increasing R&D costs, decreasing number of new drug molecules being launched, several blockbuster drugs falling off the patent cliff, and a high proportion of advanced drug candidates exhibiting poor aqueous solubility. The traditional approach of salt formulation to improve drug solubility is unsuccessful with molecules that lack ionizable functional groups, have sensitive moieties that are prone to decomposition/racemization, and/or are not sufficiently acidic/basic to enable salt formation. Several novel examples of pharmaceutical cocrystals from the past decade are reviewed, and the enhanced solubility profiles of cocrystals are analyzed. The peak dissolution for pharmaceutical cocrystals occurs in a short time (<30 min), and high solubility is maintained over a sufficiently long period (4–6 h) for the best cases. The enhanced solubility of drug cocrystals is similar to the supersaturation phenomenon ...
818 citations
TL;DR: The physical and chemical stability of drug nanoparticles, including their mechanisms and corresponding characterization techniques are reviewed, and a few common strategies to overcome stability issues are discussed.
768 citations