S
Sasha Moola
Researcher at Stellenbosch University
Publications - 3
Citations - 2280
Sasha Moola is an academic researcher from Stellenbosch University. The author has contributed to research in topics: Selection (genetic algorithm) & Bayesian probability. The author has an hindex of 3, co-authored 3 publications receiving 1815 citations. Previous affiliations of Sasha Moola include University of Cape Town.
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Journal ArticleDOI
Detecting individual sites subject to episodic diversifying selection.
Ben Murrell,Ben Murrell,Joel O. Wertheim,Sasha Moola,Thomas Weighill,Konrad Scheffler,Konrad Scheffler,Sergei L. Kosakovsky Pond +7 more
TL;DR: It is found that episodic selection is widespread and it is concluded that the number of sites experiencing positive selection may have been vastly underestimated.
Journal ArticleDOI
FUBAR : A Fast, Unconstrained Bayesian AppRoximation for inferring selection
Ben Murrell,Sasha Moola,Sasha Moola,Amandla Mabona,Amandla Mabona,Thomas Weighill,Daniel J. Sheward,Sergei L. Kosakovsky Pond,Konrad Scheffler,Konrad Scheffler +9 more
TL;DR: This work presents an approximate hierarchical Bayesian method using a Markov chain Monte Carlo (MCMC) routine that ensures robustness against model misspecification by averaging over a large number of predefined site classes, and leaves the distribution of selection parameters essentially unconstrained.
Journal ArticleDOI
Non-Negative Matrix Factorization for Learning Alignment-Specific Models of Protein Evolution
Ben Murrell,Ben Murrell,Thomas Weighill,Jan Buys,Robert Ketteringham,Sasha Moola,Gerdus Benade,Lise du Buisson,Daniel Kaliski,Tristan Hands,Konrad Scheffler +10 more
TL;DR: A method for estimating alignment-specific models of protein evolution in which the complexity of the model is adapted to suit the richness of the data, and the basis matrices obtained confirm the expectation that amino acid properties tend to be conserved and allow us to quantify, on specific alignments, how the strength of conservation varies across different properties.