S
Saskia Lippens
Researcher at Ghent University
Publications - 83
Citations - 7062
Saskia Lippens is an academic researcher from Ghent University. The author has contributed to research in topics: Caspase 14 & Programmed cell death. The author has an hindex of 32, co-authored 79 publications receiving 5723 citations. Previous affiliations of Saskia Lippens include Flanders Institute for Biotechnology.
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Journal ArticleDOI
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
Ellen Wirawan,L Vande Walle,Kristof Kersse,Sigrid Cornelis,Sigrid Cornelis,Sofie Claerhout,Isabel Vanoverberghe,Ria Roelandt,R. De Rycke,Jelle Verspurten,Wim Declercq,Patrizia Agostinis,T Vanden Berghe,Saskia Lippens,Peter Vandenabeele +14 more
TL;DR: Findings point to a mechanism by which casp-dependent generation of Beclin-1-C creates an amplifying loop enhancing apoptosis upon growth factor withdrawal.
Journal ArticleDOI
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Charlotte L. Scott,Fang Zheng,Fang Zheng,Patrick De Baetselier,Liesbet Martens,Yvan Saeys,Sofie De Prijck,Saskia Lippens,Chloé Abels,Steve Schoonooghe,Geert Raes,Nick Devoogdt,Bart N. Lambrecht,Alain Beschin,Martin Guilliams +14 more
TL;DR: It is shown that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells, like embryonic precursors if the niche is available to them.
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Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality
Quinten Remijsen,Taco W. Kuijpers,Ellen Wirawan,Saskia Lippens,Peter Vandenabeele,T Vanden Berghe +5 more
TL;DR: The recent progress made in the identification of the mechanisms involved in NETosis is described and its interplay with autophagy and apoptosis is discussed.
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Autophagy: for better or for worse
TL;DR: This review gives a comprehensive overview of the autophagic signaling pathway, its role in general cellular processes and its connection to cell death, and a brief summary of the possible contribution of defective autophagy signaling to disease.
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Cell death by cornification.
TL;DR: An overview of the current concept of cornification as a mode of programmed cell death and the anti-cell death mechanisms in the epidermis that secure epidermal homeostasis is given.