Satenik Mkrtchyan

Journal ArticleDOI

Synthesis of fluorinated purine and 1-deazapurine glycosides as potential inhibitors of adenosine deaminase.

- 23 Mar 2011 -

TL;DR: The synthesis of 2- and 6-trifluoromethylated purines and 1-deazapurines was performed by formal [3 + 3]-cyclization reactions of 5-aminoimidazoles and can be considered as potential inhibitors of adenosine deaminase (ADA).

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Journal ArticleDOI

4-Chloro-3-(trifluoroacetyl)- and 4-chloro-3-(methoxalyl)coumarins as novel and efficient building blocks for the regioselective synthesis of 3,4-fused coumarins

Viktor O. Iaroshenko, +12 more

- 14 Oct 2011 -

Tetrahedron

TL;DR: In this article, the starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride.

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Journal ArticleDOI

3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis

Satenik Mkrtchyan, +13 more

- 23 Dec 2010 -

Organic and Biomolecular Chemistry

TL;DR: The first synthesis of 3-methoxalylchromone was described, where the reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO(2)Me substituent located at the α-position of the pyridine core.

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Journal ArticleDOI

A general strategy for the synthesis of difluoromethyl-containing pyrazoles, pyridines and pyrimidines

Viktor O. Iaroshenko, +8 more

- 05 Aug 2011 -

Tetrahedron

TL;DR: In this paper, the CF 2 Cl-substituted 1,3-dicarbonyl compounds were used to obtain difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles.

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Journal ArticleDOI

2,3-Unsubstituted chromones and their enaminone precursors as versatile reagents for the synthesis of fused pyridines

Viktor O. Iaroshenko, +9 more

- 28 Jan 2012 -

Organic and Biomolecular Chemistry

TL;DR: A divergent and regioselective approach to fused pyridines was developed through formal [3 + 3] cyclocondensations from simple 2,3-unsubstituted chromones or their enaminone precursors.

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Papers

Synthesis of fluorinated purine and 1-deazapurine glycosides as potential inhibitors of adenosine deaminase.

4-Chloro-3-(trifluoroacetyl)- and 4-chloro-3-(methoxalyl)coumarins as novel and efficient building blocks for the regioselective synthesis of 3,4-fused coumarins

3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis

A general strategy for the synthesis of difluoromethyl-containing pyrazoles, pyridines and pyrimidines

2,3-Unsubstituted chromones and their enaminone precursors as versatile reagents for the synthesis of fused pyridines