S
Satish Menon
Publications - 34
Citations - 12595
Satish Menon is an academic researcher. The author has contributed to research in topics: Cytokine & Interleukin 10. The author has an hindex of 26, co-authored 31 publications receiving 12100 citations.
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Journal ArticleDOI
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Vassili Soumelis,Pedro A. Reche,Holger Kanzler,Wei Yuan,Gina Edward,Bernhart Homey,Michel Gilliet,Steve Ho,Svetlana Antonenko,Annti Lauerma,Kathleen M. Smith,Daniel M. Gorman,Sandra Zurawski,Jon Abrams,Satish Menon,Terri McClanahan,Rene de Waal-Malefyt,Fernando Bazan,Robert A. Kastelein,Yong-Jun Liu +19 more
TL;DR: It is shown that human thymic stromal lymphopoietin (TSLP) potently activated CD11c+ dendritic cells (DCs) and induced production of the TH2-attracting chemokines TARC (thymus and activation-regulated chemokine) and MDC (macrophage-derivedChemokine; CCL22).
Journal ArticleDOI
Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells.
Fiona Powrie,Michael W. Leach,Smita Mauze,Satish Menon,Linda Barcomb Caddle,Robert L. Coffman +5 more
TL;DR: The mechanism of pathogenesis of IBD in this model is dissected and the administration of anti-IFN gamma MAb to mice soon after T cell transfer prevented development of colitis for up to 12 weeks.
Journal ArticleDOI
IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.
Madeline M. Fort,Jeanne Cheung,David C. Yen,Joana Li,Sandra Zurawski,Sylvia Lo,Satish Menon,Teresa Clifford,Brisdell Hunte,Robin Lesley,Tony Muchamuel,Stephen D. Hurst,Gerard Zurawski,Michael W. Leach,Daniel M. Gorman,Donna Rennick +15 more
TL;DR: The results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types.
Journal ArticleDOI
Enterocolitis and colon cancer in interleukin-10 : deficient mice are associated with aberrant cytokine production and cd4+ th1-like responses
Daniel J. Berg,Natalle Davidson,Ralf Kühn,Werner Müller,Satish Menon,Gina Holland,Luann Thompson-Snipes,Michael W. Leach,Donna M. Rennick +8 more
TL;DR: The authors characterized the progressive stages of chronic intestinal inflammation that develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in the IL-10 gene (IL-10-/-) and showed that inflammatory changes first appear in the cecum, ascending and transverse colon of 3-week-old mutants.
Journal ArticleDOI
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.
J. Punnonen,G Aversa,Benjamin G. Cocks,Andrew Mckenzie,Satish Menon,G Zurawski,R de Waal Malefyt,J E de Vries +7 more
TL;DR: IL-13 is another T-cell-derived cytokine that, in addition to IL-4, efficiently directs naive human B cells to switch to IgG4 and IgE production, suggesting that common signaling pathways may be involved.