Satoru Masamune

TL;DR: In this article, it is shown that double asymmetric induction can be analyzed in terms of the single asymmetric reactions of each of the two chiral reactants, and a new strategy based on this rule for the predictable creation of new chiral centers is discussed and the use of this strategy for the synthesis of sugars and macrolides is presented.

TL;DR: A mild olefination procedure, utilizing LiCl and an amine, has been developed for use with base-sensitive aldehydes and phosphonates as discussed by the authors.

TL;DR: Bisoxazolines (1, 7) prepared from diethyl malonate and chiral amino alcohols were converted into their Cu(II) complexes which, upon activation, exhibit high enantioselectivity of up to 99 %ee for catalytic cyclopropanation of olefins as discussed by the authors.

TL;DR: Analysis of hydrolytic products of poly(3-hydroxybutyrate), several oligomeric esters of D(--)-3-Hydroxybutyric acid, and the methyl ester of the trimeric ester indicated that the enzyme hydrolyzed these substrates from the free hydroxyl terminus, releasing D(.--)-3,hydroxy butyrate dimer units one at a time.

TL;DR: In this article, a review of the organometallic chemistry of the Group 14 elements E = Si, Ge, Sn in the 1980's is highlighted by the successful construction and characterization of three systems previously thought to be too reactive to exist: (1) three-membered ring compounds including cyclotrisilane, cyclotrigermane, and cyclotristannane, (2) molecules containing EE double bonds including disilene, digermene and distannene, and (3) strained polycyclo[1.1.