Satria A. Kautsar

TL;DR: The thoroughly updated antiSMASH version 4 is presented, which adds several novel features, including prediction of gene cluster boundaries using the ClusterFinder method or the newly integrated CASSIS algorithm, improved substrate specificity prediction for non-ribosomal peptide synthetase adenylation domains based on the new SANDPUMA algorithm, and several usability features have been updated and improved.

TL;DR: Two bioinformatic tools enable sequence similarity network and phylogenetic analysis of gene clusters and their families across hundreds of strains and in large datasets, leading to the discovery of new natural products.

TL;DR: MIBiG 2.0 is presented, which encompasses major updates to the schema, the data, and the online repository itself, and improves the user experience by adding new features such as query searches and a statistics page, and enabled direct link-outs to chemical structure databases.

TL;DR: Applied on 48 high-quality plant genomes, plantiSMASH identifies a rich diversity of candidate plant BGCs, spurred by the continuing decrease in costs of plant genome sequencing, they will allow genome mining technologies to be applied to plant natural product discovery.

TL;DR: BiG-FAM is presented, a database of 29,955 GCFs capturing the global diversity of 1,225,071 BGCs predicted from 209,206 publicly available microbial genomes and metagenome-assembled genomes (MAGs).