S
Scott A. Lesley
Researcher at Genomics Institute of the Novartis Research Foundation
Publications - 228
Citations - 11706
Scott A. Lesley is an academic researcher from Genomics Institute of the Novartis Research Foundation. The author has contributed to research in topics: Thermotoga maritima & Structural genomics. The author has an hindex of 46, co-authored 227 publications receiving 10590 citations. Previous affiliations of Scott A. Lesley include Promega & Novartis.
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Journal ArticleDOI
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
William R. Wikoff,Andrew T. Anfora,Jun Liu,Peter G. Schultz,Scott A. Lesley,Eric C. Peters,Gary Siuzdak +6 more
TL;DR: A broad, drug-like phase II metabolic response of the host to metabolites generated by the microbiome was observed, suggesting that the gut microflora has a direct impact on the drug metabolism capacity of theHost.
Journal ArticleDOI
Protein production and purification.
Susanne Gräslund,Pär Nordlund,J Weigelt,B M Hallberg,James E. Bray,Opher Gileadi,Stefan Knapp,Udo Oppermann,Cheryl H. Arrowsmith,Raymond Hui,J Ming,Sirano Dhe-Paganon,Park H-W.,Alexei Savchenko,Adelinda Yee,Aled M. Edwards,Renaud Vincentelli,Christian Cambillau,R Kim,Kim S-H.,Zihe Rao,Yunyu Shi,Thomas C. Terwilliger,Kim C-Y.,Hung L-W.,Geoffrey S. Waldo,Yoav Peleg,Shira Albeck,Tamar Unger,Orly Dym,Jaime Prilusky,Joel L. Sussman,Raymond C. Stevens,Scott A. Lesley,Scott A. Lesley,Ian A. Wilson,Ian A. Wilson,Andrzej Joachimiak,Frank R. Collart,Irina Dementieva,Mark I. Donnelly,William H. Eschenfeldt,Youngchang Kim,Lucy Stols,Ruiying Wu,M. Zhou,Stephen K. Burley,J.S. Emtage,J.M. Sauder,D.A. Thompson,Kevin Bain,John G. Luz,Tarun Gheyi,F Zhang,Shane Atwell,Steven C. Almo,Jeffrey B. Bonanno,Andras Fiser,Soumya Swaminathan,F.W. Studier,Mark R. Chance,Andrej Sali,Thomas Acton,Rong Xiao,L Zhao,L C Ma,John F. Hunt,Liang Tong,Kellie Cunningham,Masayori Inouye,Stephen Anderson,Haleema Janjua,Ritu Shastry,C K Ho,D Wang,Hao Wang,M Jiang,Gaetano T. Montelione,David I. Stuart,Raymond J. Owens,S Daenke,Anja Schütz,Udo Heinemann,S Yokoyama,Konrad Büssow,Kristin C. Gunsalus,Kristin C. Gunsalus +86 more
TL;DR: This review presents methods that could be applied at the outset of any project, a prioritized list of alternate strategies and a list of pitfalls that trip many new investigators.
Journal ArticleDOI
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
Scott A. Lesley,Peter Kuhn,Adam Godzik,Ashley M. Deacon,I.I. Mathews,Andreas Kreusch,Glen Spraggon,Heath E. Klock,Daniel McMullan,Tanya Shin,Juli Vincent,Alyssa Robb,Linda S. Brinen,M. Miller,Timothy M. McPhillips,Mark A. Miller,Daniel Scheibe,Jaume M. Canaves,Chittibabu Guda,Lukasz Jaroszewski,Thomas L. Selby,Marc-André Elsliger,John Wooley,Susan S. Taylor,Keith O. Hodgson,Ian A. Wilson,Peter G. Schultz,Raymond C. Stevens +27 more
TL;DR: The design and implementation of a high-throughput structural genomics pipeline and its application to the proteome of the thermophilic bacterium Thermotoga maritima is described and successfully cloned and attempted expression of 1,376 of the predicted 1,877 genes.
Journal ArticleDOI
Co-regulatory networks of human serum proteins link genetics to disease
Valur Emilsson,Marjan Ilkov,John Lamb,Nancy Finkel,Elias F. Gudmundsson,Rebecca Pitts,Heather Hoover,Valborg Gudmundsdottir,Shane R. Horman,Thor Aspelund,Le Shu,Vladimir Trifonov,Sigurdur Sigurdsson,Andrei Manolescu,Jun Zhu,Orn Olafsson,Johanna Jakobsdottir,Scott A. Lesley,Jeremy To,Jia Zhang,Tamara B. Harris,Lenore J. Launer,Bin Zhang,Gudny Eiriksdottir,Xia Yang,Anthony P. Orth,Lori L. Jennings,Vilmundur Gudnason +27 more
TL;DR: A deep proteome analysis of human serum reveals the relationship between disease and genetics and revealed co-regulated groups of circulating proteins that incorporated regulatory control between tissues and demonstrated close relationships to past, current, and future disease states.
Journal ArticleDOI
XtalPred: a web server for prediction of protein crystallizability.
Lukasz Slabinski,Lukasz Jaroszewski,Leszek Rychlewski,Ian A. Wilson,Scott A. Lesley,Adam Godzik +5 more
TL;DR: XtalPred provides a detailed comparison of the protein's features to the corresponding distribution from TargetDB, a summary of protein features and predictions that indicate problems that are likely to be encountered during protein crystallization, and lists of close homologs from complete microbial genomes that are more likely to crystallize.