Scott Duncan

Bio: Scott Duncan is an academic researcher from Mercer University. The author has contributed to research in topics: Cycloaddition & Intramolecular force. The author has an hindex of 3, co-authored 10 publications receiving 1062 citations. Previous affiliations of Scott Duncan include Alkermes.

Prodrugs of fumarates and their use in treating various diseases

Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

Application of Commercial Microwave Ovens to Organic Synthesis.

Abstract: Commercial microwave ovens have been safely used to dramatically reduce the reaction times (at comparable yield) of Diels-Alder, Claisen, and ene reactions. Significant solvent effects were also observed.

Process for the synthesis of 3-cyano-6-alkoxy-7-nitro-4-quinolines

Abstract: There is provided a process for the preparation of 3-cyano-6-alkoxy-7-nitro-4­-quinolone intermediates useful for the preparation of protein tyrosine kinase (PTK) inhibitors which are useful in the treatment of cancer of the formula, wherein R is alkyl(C,-C3) prepared by reacting a substituted anthranilate with N,N­dimethylformamide dimethyacetal to obtain a N,N-dimethylamidine which is condensed with t-butylcyanoacetate to obtain a N-(2-cyano-2-t­butoxycarbonylvinyl)anthranilate, which is hydrolyzed to yield a N-(2-cyano-2­carboxyvinyl)anthranilate followed by decarboxylating to obtain a N-(2-cyano-2­ carboxyvinyl)anthranilate followed by cyclizing to obtain a 3-cyano-6-alkoxy-7-nitro-4­quinolone.

Controlled microwave heating in modern organic synthesis.

Abstract: Although fire is now rarely used in synthetic chemistry, it was not until Robert Bunsen invented the burner in 1855 that the energy from this heat source could be applied to a reaction vessel in a focused manner. The Bunsen burner was later superseded by the isomantle, oil bath, or hot plate as a source for applying heat to a chemical reaction. In the past few years, heating and driving chemical reactions by microwave energy has been an increasingly popular theme in the scientific community. This nonclassical heating technique is slowly moving from a laboratory curiosity to an established technique that is heavily used in both academia and industry. The efficiency of "microwave flash heating" in dramatically reducing reaction times (from days and hours to minutes and seconds) is just one of the many advantages. This Review highlights recent applications of controlled microwave heating in modern organic synthesis, and discusses some of the underlying phenomena and issues involved.

Microwave chemistry for inorganic nanomaterials synthesis

Abstract: This Feature Article gives an overview of microwave-assisted liquid phase routes to inorganic nanomaterials. Whereas microwave chemistry is a well-established technique in organic synthesis, its use in inorganic nanomaterials' synthesis is still at the beginning and far away from having reached its full potential. However, the rapidly growing number of publications in this field suggests that microwave chemistry will play an outstanding role in the broad field of Nanoscience and Nanotechnology. This article is not meant to give an exhaustive overview of all nanomaterials synthesized by the microwave technique, but to discuss the new opportunities that arise as a result of the unique features of microwave chemistry. Principles, advantages and limitations of microwave chemistry are introduced, its application in the synthesis of different classes of functional nanomaterials is discussed, and finally expected benefits for nanomaterials' synthesis are elaborated.