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Scott L. Childs
Researcher at Cephalon
Publications - 13
Citations - 2882
Scott L. Childs is an academic researcher from Cephalon. The author has contributed to research in topics: Cocrystal & Crystal structure. The author has an hindex of 10, co-authored 13 publications receiving 2646 citations. Previous affiliations of Scott L. Childs include Wilmington University.
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Journal ArticleDOI
The Salt−Cocrystal Continuum: The Influence of Crystal Structure on Ionization State
TL;DR: Modifications to the DeltapK(a) rule for selecting salt screen counterions are proposed that focus on the discovery of solid forms with useful physical properties rather than an arbitrary cutoff value for Deltam(a).
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Use of a glutaric acid cocrystal to improve oral bioavailability of a low solubility API.
Daniel P. McNamara,Scott L. Childs,Jennifer Giordano,Anthony Iarriccio,James Cassidy,Manjunath S. Shet,Richard Owen Mannion,Edward Patrick O'donnell,Aeri Park +8 more
TL;DR: Use of the cocrystal increased the aqueous dissolution rate by 18 times as compared to the homomeric crystalline form of the drug and showed that it is unique regarding thermal, spectroscopic, X-ray, and dissolution properties.
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Crystal Engineering Approach To Forming Cocrystals of Amine Hydrochlorides with Organic Acids. Molecular Complexes of Fluoxetine Hydrochloride with Benzoic, Succinic, and Fumaric Acids
Scott L. Childs,Leonard J. Chyall,Jeanette T. Dunlap,Valeriya N Smolenskaya,Barbara C. Stahly,G. Patrick Stahly +5 more
TL;DR: A crystal engineering strategy for designing cocrystals of pharmaceuticals increases the probability of discovering useful cocry crystals and decreases the number of experiments that are needed by selecting API:guest combinations that have the greatest potential of forming energetically and structurally robust interactions.
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Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine
Scott L. Childs,Naír Rodríguez-Hornedo,L. Sreenivas Reddy,Adivaraha Jayasankar,Chinmay Maheshwari,Linda McCausland,Rex Shipplett,Barbara C. Stahly +7 more
TL;DR: In this paper, four different screening techniques were used to form cocrystals of carbamazepine containing pharmaceutically acceptable carboxylic acids, including phase solubility diagrams and triangular phase diagrams.
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Formulation of a Danazol Cocrystal with Controlled Supersaturation Plays an Essential Role in Improving Bioavailability
TL;DR: In the case of the danazol:vanillin cocystal, using a combination of cocrystal, solubilizer, and precipitation inhibitor in a designed supersaturating drug delivery system resulted in a dramatic improvement in the bioavailability.