Scott M. Grundy

TL;DR: Observations suggest that lovastatin may be of potential benefit in decreasing the atherosclerotic complications of hypertriglyceridemia.

TL;DR: Angina in the absence of subclinical atherosclerosis is not related to many traditional atherosclerotic risk factors but is associated with clinical, inflammatory, and vascular factors that reflect endothelial dysfunction and vascular stiffness, suggesting a distinct vascular etiology and alternative potential therapeutic targets.

TL;DR: In this paper, factors regulating the concentrations of plasma low density lipoproteins (LDL), apolipoprotein B metabolism was studied in nine Pima Indians (25 +/- 2 yr, 191 +/- 20% ideal wt) with low LDL cholesterol and apoB (60 +/- 4 mg/dl) and in eight age-and weight-matched Caucasians with similar very lowdensity lipoprotein (VLDL) concentrations, but higher LDL (cholesterol = 104 +/- 18; apoprotein B = 82 +/- 10; P less than 0.05).

TL;DR: Overall, replacement of total cholesterol and HDL-C with apolipoproteins or their ratios was not associated with improved CVD risk prediction, whereas adding lipoprotein factors to total cholesterol or low-densitylipoprotein cholesterol was associated with slight improvement in CVDrisk prediction.

TL;DR: The patient with advanced planar xanthomatosis and benign monoclonal gammopathy who had normal plasma concentrations of cholesterol and triglycerides had changes in the metabolism of TG-containing lipoproteins that could be explained by both enhanced tissue uptake and increased lipolysis of VLDL-TG.