Scott M. Grundy

TL;DR: Changes in the metabolism of cholesterol, bile acids, and triglycerides in the patients of this study suggests that polyunsaturated fats may cause a lowering of cholesterol through multiple mechanisms, and it seems unlikely that a single action can explain all the effects of these fats on the plasma lipids.

TL;DR: It was concluded that during the steady state duodenal outputs corresponded to rates of hepatic secretion, and a continuous pattern of total lipid composition of bile was obtained during the period of formula feeding.

TL;DR: The hypocholesterolemic effect of PUSF was uniform for all lipoproteins and usually was accompanied by a corresponding decrease in concentrations of apoprotein constituents and there were no changes in cholesterol/apoB or triglyceride-to-apoB ratios in VLDL despite a 23% decrease in plasma triglycerides on P USF.

TL;DR: An inappropriately elevated rate of production of both cholesterol and LDL as well as a reduced fractional catabolic rate for the lipoprotein in the untreated FH homozygote are consistent with results of studies in cultured fibroblasts indicating that the primary genetic defect in FH involves a deficiency in a cell-surface receptor for LDL that regulates both cholesterol synthesis and LDL degradation.

TL;DR: It is indicated that the judicious addition of beta-sitosterol orbeta-sitosteryl oleate to meals containing cholesterol-rich foods will result in a significant decrease in cholesterol absorption, with a consequent decrease in plasma cholesterol.