S
Scott M. Grundy
Researcher at University of Texas Southwestern Medical Center
Publications - 849
Citations - 246629
Scott M. Grundy is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 187, co-authored 841 publications receiving 231821 citations. Previous affiliations of Scott M. Grundy include University of California, San Francisco & University of California, Davis.
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Journal ArticleDOI
Lovastatin therapy in receptor-negative homozygous familial hypercholesterolemia: lack of effect on low-density lipoprotein concentrations or turnover.
TL;DR: It is concluded that lovastatin is not effective in treatment of receptor-negative homozygous familial hypercholesterolemia, and the most likely mechanism of action for this drug is to increase LDL receptor activity.
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What is the contribution of obesity to the metabolic syndrome
TL;DR: It is worthwhile to investigate individually the components of the obesity-induced metabolic syndrome for their atherogenic potential, because out of that investigation likely will come new targets for clinical or public health intervention to reduce the risk for cardiovascular disease.
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Integrated study of low density lipoprotein metabolism and very low density lipoprotein metabolism in non-insulin-dependent diabetes.
Barbara V. Howard,William G H Abbott,William F. Beltz,Ingeborg T. Harper,Rose M. Fields,Scott M. Grundy,Marja Riita Taskinen +6 more
TL;DR: The data indicate that the triglyceride-rich VLDL in non-insulin-dependent diabetics are less readily converted to LDL, whereas the elevated LDL in this group of diabetICS is due to impaired clearance.
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Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population.
Thomas P. Bersot,Gloria Lena Vega,Scott M. Grundy,K.E. Palaoglu,Pamir Atagündüz,Sinan Özbayrakçı,O Gökdemir,Robert W. Mahley +7 more
TL;DR: Investigating the cause of low HDL-C levels in Turks found the elevation most likely has a genetic basis, as no dietary or behavioral factors have been identified in the Turkish population that account for increased hepatic triglyceride lipase activity.
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The Effect of Continuous Subcutaneous Insulin Infusion on Very-Low-Density Lipoprotein Triglyceride Metabolism in Type I Diabetes Mellitus
TL;DR: The mechanism responsible for the observed change in plasma triglyceride levels in normolipidemic type I diabetic patients that occurs with 3 wk of CSII treatment is due to suppression of hepatic VLDL-TG synthesis rather than the result of increased lipoprotein clearance.