Scott Valastyan

TL;DR: The invasion-metastasis cascade is a multistep cell-biological process that involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments as mentioned in this paper.

TL;DR: It is shown that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness, and a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasis

TL;DR: In this article, the authors uncover a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasissuppressing protein E-cadherin.

TL;DR: Findings indicate that miR-31 uses multiple mechanisms to oppose metastasis, including coordinate repression of a cohort of metastasis-promoting genes, including RhoA.

TL;DR: This research highlights the need to understand more fully the role of immune checkpoints in the development of central nervous system disease and the role that these checkpoints play in the progression of certain types of cancer.