S
Seamus Sreenan
Researcher at Royal College of Surgeons in Ireland
Publications - 80
Citations - 2952
Seamus Sreenan is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Diabetes mellitus & Insulin. The author has an hindex of 24, co-authored 73 publications receiving 2667 citations. Previous affiliations of Seamus Sreenan include Memorial Hospital of South Bend & University of Medicine and Health Sciences.
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Journal ArticleDOI
Troglitazone Action Is Independent of Adipose Tissue
Charles F. Burant,Seamus Sreenan,Ken-Ichi Hirano,Tzu Ann C. Tai,Jeffrey J. Lohmiller,John N. Lukens,Nicholas O. Davidson,Susan R. Ross,Reed A. Graves +8 more
TL;DR: The results demonstrate that insulin resistance and diabetes can occur in animals without significant adipose deposits and troglitazone can alter glucose and lipid metabolism independent of its effects on adipose tissue.
Journal ArticleDOI
Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.
Marco Pontoglio,Seamus Sreenan,Michael W. Roe,W. Pugh,Diane Ostrega,Antonia Doyen,Anthony Pick,Aaron C. Baldwin,G. Velho,Philippe Froguel,Matteo G. Levisetti,Susan Bonner-Weir,Graeme I. Bell,Moshe Yaniv,Kenneth S. Polonsky +14 more
TL;DR: A null mutation in the HNF-1alpha gene in homozygous mice leads to diabetes due to alterations in the pathways that regulate beta cell responses to secretagogues including glucose and arginine.
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Visualizing superoxide production in normal and diabetic rat islets of Langerhans.
Vytautas P. Bindokas,Andrey V. Kuznetsov,Seamus Sreenan,Kenneth S. Polonsky,Michael W. Roe,Louis H. Philipson +5 more
TL;DR: Overproduction of superoxide was associated with perturbed mitochondrial morphology and may contribute to abnormal glucose signaling found in the Zucker diabetic fatty model of type 2 diabetes mellitus.
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Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.
Seamus Sreenan,Anthony Pick,Matteo G. Levisetti,Aaron C. Baldwin,W. Pugh,Kenneth S. Polonsky +5 more
TL;DR: It is suggested that in the NOD mouse, beta-cell destruction begins soon after the onset of insulitis, andBeta-cell mass progressively falls and is significantly reduced by 13 weeks despite normal blood glucose concentrations, suggesting diabetes may be present when residual beta- cell mass represents 30% of control levels.
Journal ArticleDOI
Calpains Play a Role in Insulin Secretion and Action
Seamus Sreenan,Yun Ping Zhou,Kenichi Otani,Kenichi Otani,Polly A. Hansen,Kevin P. M. Currie,Chien-Yuan Pan,Jean Pyo Lee,Diane Ostrega,W. Pugh,Yukio Horikawa,Yukio Horikawa,Nancy J. Cox,Craig L. Hanis,Charles F. Burant,Aaron P. Fox,Graeme I. Bell,Kenneth S. Polonsky +17 more
TL;DR: It is reported that short-term exposure to the cell-permeable calpain inhibitors calpain inhibitor II and E-64-d increases the insulin secretory response to glucose in mouse pancreatic islets and is consistent with a role for calpains in the regulation of insulin secretion and insulin action.