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Sean D. Mooney

Researcher at University of Washington

Publications -  179
Citations -  19191

Sean D. Mooney is an academic researcher from University of Washington. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 44, co-authored 168 publications receiving 15958 citations. Previous affiliations of Sean D. Mooney include Stanford University & Indiana University – Purdue University Indianapolis.

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Comprehensive molecular portraits of human breast tumours

Daniel C. Koboldt, +355 more
- 04 Oct 2012 - 
TL;DR: The ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity.
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A large-scale evaluation of computational protein function prediction

Predrag Radivojac, +107 more
- 01 Mar 2013 - 
TL;DR: Today's best protein function prediction algorithms substantially outperform widely used first-generation methods, with large gains on all types of targets, and there is considerable need for improvement of currently available tools.
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Automated inference of molecular mechanisms of disease from amino acid substitutions

Biao Li, +7 more
- 01 Nov 2009 - 
TL;DR: A new computational model, MutPred, is developed that is based upon protein sequence, and which models changes of structural features and functional sites between wild-type and mutant sequences and can provide insight into the specific molecular mechanism responsible for the disease state.
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Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

Matthew J. Rardin, +10 more
- 16 Apr 2013 - 
TL;DR: Data show that SIRT3 regulates acetylation on multiple proteins, often at multiple sites, across several metabolic pathways including fatty acid oxidation, ketogenesis, amino acid catabolism, and the urea and tricarboxylic acid cycles, as well as mitochondrial regulatory proteins.
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Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.

Mahru C. An, +7 more
- 03 Aug 2012 - 
TL;DR: It is reported that human induced pluripotent stem cells derived from HD patient fibroblasts can be corrected by the replacement of the expanded CAG repeat with a normal repeat using homologous recombination, and that the correction persists in iPSC differentiation into DARPP-32-positive neurons in vitro and in vivo.