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Sean W. Smith

Bio: Sean W. Smith is an academic researcher from Dartmouth College. The author has contributed to research in topics: Authentication & Public key infrastructure. The author has an hindex of 48, co-authored 252 publications receiving 8429 citations. Previous affiliations of Sean W. Smith include King's College London & George Mason University.


Papers
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Journal ArticleDOI
30 Nov 2017-Cell
TL;DR: It is found that HLA LOH occurs in 40% of non-small-cell lung cancers (NSCLCs) and is associated with a high subclonal neoantigen burden, APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity.

850 citations

Journal ArticleDOI
TL;DR: It is concluded that cirrhosis, especially when complicated with HE, is associated with significant alterations in the stool microbiome compared with healthy individuals.
Abstract: Hepatic encephalopathy (HE) has been related to gut bacteria and inflammation in the setting of intestinal barrier dysfunction. We aimed to link the gut microbiome with cognition and inflammation i...

447 citations

Journal ArticleDOI
TL;DR: Some of issues the authors faced when attempting to build a high-performance secure coprocessor that balances security with easy third-party programmability are discussed.

412 citations

Journal ArticleDOI
18 Apr 2017-Immunity
TL;DR: Use of an anti‐CD25 antibody with enhanced binding to activating Fc&ggr;Rs led to effective depletion of tumor‐infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors.

315 citations

Journal ArticleDOI
Joan G. Dyer1, Mark Lindemann, Ronald Perez, Reiner Sailer, L. van Doorn, Sean W. Smith 
TL;DR: The 4758 is a lifetime-secure tamper-responding device, a multipurpose programmable device based on a 99-MHz 486 CPU internal environment, with a real operating system, a C language development environment and relatively high-speed cryptography.
Abstract: Meeting the challenge of building a user-configurable secure coprocessor provided several lessons in hardware and software development and continues to spur further research. In developing the 4758, we met our major research security goals and provided the following features: (1) a lifetime-secure tamper-responding device, rather than one that is secure only between resets that deployment-specific security officers perform; (2) a secure booting process in which each layer progressively validates the next less-trusted layer, with hardware restricting access to its secrets before passing control to that layer; (3) an actual manufacturable product - a nontrivial accomplishment considering that we designed the device so that it does not have a personality until configured in the field; (4) the first FIPS 140-1 Level 4 validation, arguably the only general-purpose computational platform validated at this level so far; and (5) a multipurpose programmable device based on a 99-MHz 486 CPU internal environment, with a real operating system, a C language development environment and relatively high-speed cryptography.

302 citations


Cited by
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Journal ArticleDOI
TL;DR: Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis.
Abstract: Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

13,246 citations

Patent
30 Sep 2010
TL;DR: In this article, the authors proposed a secure content distribution method for a configurable general-purpose electronic commercial transaction/distribution control system, which includes a process for encapsulating digital information in one or more digital containers, a process of encrypting at least a portion of digital information, a protocol for associating at least partially secure control information for managing interactions with encrypted digital information and/or digital container, and a process that delivering one or multiple digital containers to a digital information user.
Abstract: PROBLEM TO BE SOLVED: To solve the problem, wherein it is impossible for an electronic content information provider to provide commercially secure and effective method, for a configurable general-purpose electronic commercial transaction/distribution control system. SOLUTION: In this system, having at least one protected processing environment for safely controlling at least one portion of decoding of digital information, a secure content distribution method comprises a process for encapsulating digital information in one or more digital containers; a process for encrypting at least a portion of digital information; a process for associating at least partially secure control information for managing interactions with encrypted digital information and/or digital container; a process for delivering one or more digital containers to a digital information user; and a process for using a protected processing environment, for safely controlling at least a portion of the decoding of the digital information. COPYRIGHT: (C)2006,JPO&NCIPI

7,643 citations

Proceedings ArticleDOI
20 May 2007
TL;DR: A system for realizing complex access control on encrypted data that is conceptually closer to traditional access control methods such as role-based access control (RBAC) and secure against collusion attacks is presented.
Abstract: In several distributed systems a user should only be able to access data if a user posses a certain set of credentials or attributes. Currently, the only method for enforcing such policies is to employ a trusted server to store the data and mediate access control. However, if any server storing the data is compromised, then the confidentiality of the data will be compromised. In this paper we present a system for realizing complex access control on encrypted data that we call ciphertext-policy attribute-based encryption. By using our techniques encrypted data can be kept confidential even if the storage server is untrusted; moreover, our methods are secure against collusion attacks. Previous attribute-based encryption systems used attributes to describe the encrypted data and built policies into user's keys; while in our system attributes are used to describe a user's credentials, and a party encrypting data determines a policy for who can decrypt. Thus, our methods are conceptually closer to traditional access control methods such as role-based access control (RBAC). In addition, we provide an implementation of our system and give performance measurements.

4,364 citations

ReportDOI
13 Aug 2004
TL;DR: This second-generation Onion Routing system addresses limitations in the original design by adding perfect forward secrecy, congestion control, directory servers, integrity checking, configurable exit policies, and a practical design for location-hidden services via rendezvous points.
Abstract: We present Tor, a circuit-based low-latency anonymous communication service. This second-generation Onion Routing system addresses limitations in the original design by adding perfect forward secrecy, congestion control, directory servers, integrity checking, configurable exit policies, and a practical design for location-hidden services via rendezvous points. Tor works on the real-world Internet, requires no special privileges or kernel modifications, requires little synchronization or coordination between nodes, and provides a reasonable tradeoff between anonymity, usability, and efficiency. We briefly describe our experiences with an international network of more than 30 nodes. We close with a list of open problems in anonymous communication.

3,960 citations