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Sebastian Draack

Bio: Sebastian Draack is an academic researcher from Braunschweig University of Technology. The author has contributed to research in topics: Magnetic particle imaging & Magnetic nanoparticles. The author has an hindex of 8, co-authored 18 publications receiving 180 citations.

Papers
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Journal ArticleDOI
TL;DR: A detailed signal generation of the magnetization response of magnetic nanoparticles (MNPs) as a result of externally applied magnetic fields with flux densities of several millitesla is of high in this paper.
Abstract: A detailed signal generation of the magnetization response of magnetic nanoparticles (MNPs) as a result of externally applied magnetic fields with flux densities of several millitesla is of high in...

44 citations

Journal ArticleDOI
TL;DR: In this article, a dual-frequency acquisition scheme was proposed to enhance sensitivity and contrast in the detection of different particle mobilities compared to a standard single-frequency MPI protocol, taking advantage of the fact that the magnetization response of the tracer is strongly frequency-dependent.

41 citations

Journal ArticleDOI
TL;DR: Next to their high magnetization capability, SPIONLA-HSA-Ptx have similar cytostatic effects on human breast cancer cells as pure paclitaxel, suggesting their usage for future MDT-based cancer therapy.
Abstract: Background Magnetic drug targeting (MDT) is an effective alternative for common drug applications, which reduces the systemic drug load and maximizes the effect of, eg, chemotherapeutics at the site of interest. After the conjugation of a magnetic carrier to a chemotherapeutic agent, the intra-arterial injection into a tumor-afferent artery in the presence of an external magnetic field ensures the accumulation of the drug within the tumor tissue. Materials and methods In this study, we used superparamagnetic iron oxide nanoparticles (SPIONs) coated with lauric acid and human serum albumin as carriers for paclitaxel (SPIONLA-HSA-Ptx). To investigate whether this particle system is suitable for a potential treatment of cancer, we investigated its physicochemical properties by dynamic light scattering, ζ potential measurements, isoelectric point titration, infrared spectroscopy, drug release quantification, and magnetic susceptibility measurements. The cytotoxic effects were evaluated using extensive toxicological methods using flow cytometry, IncuCyte® live-cell imaging, and growth experiments on different human breast cancer cell lines in two- and three-dimensional cell cultures. Conclusion The data showed that next to their high magnetization capability, SPIONLA-HSA-Ptx have similar cytostatic effects on human breast cancer cells as pure paclitaxel, suggesting their usage for future MDT-based cancer therapy.

36 citations

Journal ArticleDOI
TL;DR: In this paper, temperature-dependent harmonic spectra of different commercially available single-core and multi-core particle systems were investigated for the determination of dominating relaxation mechanisms of magnetic nanoparticles.

28 citations

Journal ArticleDOI
TL;DR: Both the SPaQ and MPS are highly suited to improve understanding SPION behavior, which will lead to the radical improvement of sentinel node biopsy accuracy.
Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) are used as a tracer material in sentinel node biopsies. The latter is a procedure to analyze if cancer cells have spread to lymph nodes, helping to personalize patient care. To predict SPION behavior in vivo, it is important to analyze their magnetic properties in biological environments. The superparamagnetic quantifier (SPaQ) is a new device to measure the dynamic magnetization curve of SPIONs. The magnetization curve was measured for two types of SPIONs: Resovist and SHP-25. We used three techniques: Vibrating Sample Magnetometry (VSM), Magnetic Particle Spectroscopy (MPS), and our new SPaQ. Furthermore, AC susceptibility (ACS) measurements were performed as part of the evaluation of the three techniques. SPaQ and VSM results were found to be similar. Measurement results were nearly identical in both directions, indicating minor hysteresis. However, in MPS measurements, a clear hysteresis loop was observed. Furthermore, the ACS measurements showed a pronounced Brownian maximum, indicating an optimal response for an AC frequency below 10 kHz for both particle systems. Both the SPaQ and MPS were found to be superior to VSM since measurements are faster, can be performed at room temperature, and are particularly sensitive to particle dynamics. The main difference between the SPaQ and MPS lies in the excitation sequence. The SPaQ combines an alternating magnetic field that has a low amplitude with a gradual DC offset, whereas MPS uses only an alternating field that has a large amplitude. In conclusion, both the SPaQ and MPS are highly suited to improve understanding SPION behavior, which will lead to the radical improvement of sentinel node biopsy accuracy.

22 citations


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TL;DR: A review of the development of magnetic particle imaging (MPI) since its introduction in 2005 is presented in this article, where detailed discussions on imaging sequences, reconstruction algorithms, scanner instrumentation and potential medical applications are provided.
Abstract: Tomographic imaging has become a mandatory tool for the diagnosis of a majority of diseases in clinical routine. Since each method has its pros and cons, a variety of them is regularly used in clinics to satisfy all application needs. Magnetic particle imaging (MPI) is a relatively new tomographic imaging technique that images magnetic nanoparticles with a high spatiotemporal resolution in a quantitative way, and in turn is highly suited for vascular and targeted imaging. MPI was introduced in 2005 and now enters the preclinical research phase, where medical researchers get access to this new technology and exploit its potential under physiological conditions. Within this paper, we review the development of MPI since its introduction in 2005. Besides an in-depth description of the basic principles, we provide detailed discussions on imaging sequences, reconstruction algorithms, scanner instrumentation and potential medical applications.

167 citations

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TL;DR: A new diagnostic imaging modality called magnetic particle imaging is introduced that allows for a focused theranostic approach encompassing treatment planning, treatment monitoring and spatially localized inductive heating in magnetic fluid hyperthermia.
Abstract: Magnetic fluid hyperthermia (MFH) treatment makes use of a suspension of superparamagnetic iron oxide nanoparticles, administered systemically or locally, in combination with an externally applied alternating magnetic field, to ablate target tissue by generating heat through a process called induction. The heat generated above the mammalian euthermic temperature of 37°C induces apoptotic cell death and/or enhances the susceptibility of the target tissue to other therapies such as radiation and chemotherapy. While most hyperthermia techniques currently in development are targeted towards cancer treatment, hyperthermia is also used to treat restenosis, to remove plaques, to ablate nerves and to alleviate pain by increasing regional blood flow. While RF hyperthermia can be directed invasively towards the site of treatment, non-invasive localization of heat through induction is challenging. In this review, we discuss recent progress in the field of RF magnetic fluid hyperthermia and introduce a new diagnostic imaging modality called magnetic particle imaging that allows for a focused theranostic approach encompassing treatment planning, treatment monitoring and spatially localized inductive heating.

93 citations

Journal ArticleDOI
22 Sep 2020
TL;DR: The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes CoV-19 (COVID-19), is a threat to the global healthcare system and economic security as discussed by the authors.
Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is a threat to the global healthcare system and economic security. As of Ju...

65 citations

Journal ArticleDOI
05 May 2020
TL;DR: Magnetic particle spectroscopy (MPS) also called magnetization response spectroscope (MRS) is a versatile measurement tool derived from magnetic particle imaging (MPI) as discussed by the authors.
Abstract: Magnetic particle spectroscopy (MPS), also called magnetization response spectroscopy (MRS), is a versatile measurement tool derived from magnetic particle imaging (MPI). It can be interpreted as a...

55 citations