Sebastian Haase

TL;DR: Three-dimensional structured illumination microscopy (3D-SIM) opens new and facile possibilities to analyze subcellular structures beyond the diffraction limit of the emitted light.

TL;DR: In this paper, the OMX platform enables subsecond, multicolor four-dimensional data acquisition and also provides access to subdiffraction structured illumination imaging for live fluorescence microscopy, showing that an image denoising algorithm exploits redundancy in the image sequence over space and time allows recovery of biological information from the low light level noisy images while maintaining full cell viability with no fading.

TL;DR: It is proposed that different interactions of MeCP2 with methyl cytosines, DNA and likely other heterochromatin proteins are required for Me CP2 function and their dysfunction lead to Rett syndrome.

TL;DR: In this article, an adaptive image deconvolution algorithm (AIDA) was proposed for myopic deconvolutions of multi-frame and three-dimensional data acquired through astronomical and microscopic imaging.

TL;DR: It is proposed that histone hypoacetylation is required to maintain normal heterochromatin duplication dynamics and speculated that a high histone acetylation level might increase the firing efficiency of origins and, concomitantly, advances the replication timing of distinct genomic regions.