Author
Sebastian Weis
Other affiliations: Instituto Gulbenkian de Ciência, Stanford University, Leipzig University
Bio: Sebastian Weis is an academic researcher from University of Jena. The author has contributed to research in topics: Medicine & Sepsis. The author has an hindex of 17, co-authored 68 publications receiving 1480 citations. Previous affiliations of Sebastian Weis include Instituto Gulbenkian de Ciência & Stanford University.
Topics: Medicine, Sepsis, Serology, Immunology, Antibody
Papers
More filters
••
TL;DR: It is speculated that nuclear localization of HO-1 protein may serve to up-regulate genes that promote cytoprotection against oxidative stress after exposure to hypoxia and heme or heme/hemopexin.
366 citations
••
University of Göttingen1, Örebro University2, Guy's and St Thomas' NHS Foundation Trust3, King's College London4, Charité5, Claude Bernard University Lyon 16, University of Jena7, Radboud University Nijmegen8, Agence Nationale de la Recherche9, University Hospital Heidelberg10, University of Duisburg-Essen11, University of Amsterdam12, Carlos III Health Institute13, University of Bern14, University of Barcelona15, National and Kapodistrian University of Athens16, Hebron University17, University of Modena and Reggio Emilia18, University of Medicine and Pharmacy of Craiova19, University of Bonn20
TL;DR: The authors reviewed the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels.
325 citations
••
McGill University1, Bandim Health Project2, Washington University in St. Louis3, University of Chicago4, Radboud University Nijmegen5, Dresden University of Technology6, University of Melbourne7, Baylor College of Medicine8, Icahn School of Medicine at Mount Sinai9, Eindhoven University of Technology10, University of Cape Town11, Rockefeller University12, Pasteur Institute13, Harvard University14, German Center for Neurodegenerative Diseases15, University of Naples Federico II16, New York University17, Trinity College, Dublin18, National Institutes of Health19, Vanderbilt University20, University of Bonn21, Aix-Marseille University22, University of Southern Denmark23, Cornell University24, Memorial Sloan Kettering Cancer Center25, East Tennessee State University26, Broad Institute27, Massachusetts Institute of Technology28
TL;DR: A common framework is established that describes the experimental standards for defining trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects.
Abstract: The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.
218 citations
••
TL;DR: It is demonstrated that induction of the iron-sequestering ferritin H chain in response to polymicrobial infections is critical to establish disease tolerance to sepsis and a crosstalk between adaptive responses controlling iron and glucose metabolism is required to maintain blood glucose within a physiologic range compatible with host survival.
186 citations
••
TL;DR: It is proposed here that tissue damage control underlies many of the protective effects of disease tolerance, and the mechanisms of cellular adaptation that underlie tissueDamage control in response to infection as well as sterile inflammation are explored.
142 citations
Cited by
More filters
•
28,685 citations
28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。
18,940 citations
••
TL;DR: The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
7,851 citations
••
Johns Hopkins University1, University of Barcelona2, St George's, University of London3, Taipei Veterans General Hospital4, Maastricht University5, Washington University in St. Louis6, Imperial College London7, University of Virginia8, Virginia Commonwealth University9, Thomas Jefferson University10, Beaumont Hospital11, University of Bordeaux12, Leipzig University13, University of Oklahoma14, University of Michigan15, Royal Melbourne Hospital16, University College Dublin17, Korea University18, University of Münster19, University of Birmingham20, University of Western Ontario21, Cleveland Clinic22, Harvard University23, University of Pennsylvania24, Northwestern University25, Université de Montréal26, Mayo Clinic27, Icahn School of Medicine at Mount Sinai28, University of California, Los Angeles29, National Yang-Ming University30, Loyola University Chicago31
TL;DR: This 2012 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a Task Force, convened by the Heart Rhythm Society, the European Heart Rhythm Association, and the European Cardiac Arrhythmia Society and charged with defining the indications, techniques, and outcomes of this procedure.
Abstract: During the past decade, catheter ablation of atrial fibrillation (AF) has evolved rapidly from an investigational procedure to its current status as a commonly performed ablation procedure in many major hospitals throughout the world. Surgical ablation of AF, using either standard or minimally invasive techniques, is also performed in many major hospitals throughout the world.
In 2007, an initial Consensus Statement on Catheter and Surgical AF Ablation was developed as a joint effort of the Heart Rhythm Society, the European Heart Rhythm Association, and the European Cardiac Arrhythmia Society.1 The 2007 document was also developed in collaboration with the Society of Thoracic Surgeons and the American College of Cardiology. Since the publication of the 2007 document, there has been much learned about AF ablation, and the indications for these procedures have changed. Therefore the purpose of this 2012 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a Task Force, convened by the Heart Rhythm Society, the European Heart Rhythm Association, and the European Cardiac Arrhythmia Society and charged with defining the indications, techniques, and outcomes of this procedure. Included within this document are recommendations pertinent to the design of clinical trials in the field of AF ablation, including definitions relevant to this topic.
This statement summarizes the opinion of the Task Force members based on an extensive literature review as well as their own experience. It is directed to all health care professionals who are involved in the care of patients with AF, particularly those who are undergoing, or are being considered for, catheter or surgical ablation procedures for AF. This statement is not intended to recommend or promote catheter ablation of AF. Rather the ultimate judgment regarding care of a particular patient …
2,754 citations