S
Sebastian Zeissig
Researcher at Dresden University of Technology
Publications - 96
Citations - 14274
Sebastian Zeissig is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Immune system & CD1D. The author has an hindex of 35, co-authored 83 publications receiving 12089 citations. Previous affiliations of Sebastian Zeissig include Charité & University of Kiel.
Papers
More filters
Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
Torsten Olszak,Dingding An,Sebastian Zeissig,Miguel Pinilla Vera,Julia Richter,Andre Franke,Jonathan N. Glickman,Reiner Siebert,Rebecca M. Baron,Dennis L. Kasper,Richard S. Blumberg +10 more
TL;DR: It is shown that in germ-free (GF) mice, invariant natural killer T (iNKT) cells accumulate in the colonic lamina propria and lung, resulting in increased morbidity in models of IBD and allergic asthma as compared with that of specific pathogen-free mice.
Journal ArticleDOI
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
Arthur Kaser,Ann-Hwee Lee,Andre Franke,Jonathan N. Glickman,Sebastian Zeissig,Herbert Tilg,Edward E. S. Nieuwenhuis,Darren E. Higgins,Stefan Schreiber,Laurie H. Glimcher,Richard S. Blumberg +10 more
TL;DR: It is reported that XBP1 deletion in intestinal epithelial cells (IECs) results in spontaneous enteritis and increased susceptibility to induced colitis secondary to both Paneth cell dysfunction and an epithelium that is overly reactive to inducers of IBD such as bacterial products (flagellin) and TNFalpha.
Journal ArticleDOI
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
Sebastian Zeissig,Nataly Bürgel,Dorothee Günzel,Jan F. Richter,Joachim Mankertz,Ulrich Wahnschaffe,Anton J. Kroesen,Martin Zeitz,Michael Fromm,Joerg D. Schulzke +9 more
TL;DR: Upregulation of pore-forming claudin 2 and downregulation and redistribution of sealing claudins 5 and 8 lead to altered tight junction structure and pronounced barrier dysfunction already in mild to moderately active Crohn’s disease.
Journal ArticleDOI
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Isabelle Cleynen,Isabelle Cleynen,Gabrielle Boucher,Luke Jostins,Luke Jostins,Luke Jostins,L. Philip Schumm,Sebastian Zeissig,Tariq Ahmad,Vibeke Andersen,Jane M. Andrews,Jane M. Andrews,Vito Annese,Stephan Brand,Steven R. Brant,Judy H. Cho,Mark J. Daly,Marla Dubinsky,Richard H. Duerr,Lynnette R. Ferguson,Andre Franke,Richard B. Gearry,Richard B. Gearry,Philippe Goyette,Hakon Hakonarson,Jonas Halfvarson,Johannes R. Hov,Hailang Huang,Nicholas A. Kennedy,Limas Kupčinskas,Ian C. Lawrance,James Lee,Jack Satsangi,Stephan Schreiber,Emilie Théâtre,Andrea E. van der Meulen-de Jong,Rinse K. Weersma,David C. Wilson,David C. Wilson,Miles Parkes,Severine Vermeire,John D. Rioux,John C. Mansfield,Mark S. Silverberg,Graham L. Radford-Smith,Graham L. Radford-Smith,Dermot P.B. McGovern,Jeffrey C. Barrett,Charlie W. Lees +48 more
TL;DR: The largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further understanding the biological relations between diseases.