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See Heng Wong
Researcher at Laboratory of Molecular Biology
Publications - 9
Citations - 4338
See Heng Wong is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Innate lymphoid cell & Nuocyte. The author has an hindex of 9, co-authored 9 publications receiving 3963 citations. Previous affiliations of See Heng Wong include MedImmune & University of Leicester.
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Journal ArticleDOI
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
TL;DR: The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.
Journal ArticleDOI
MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion
Christopher J. Oliphant,You Yi Hwang,Jennifer A. Walker,Maryam Salimi,See Heng Wong,James M. Brewer,Alexandros Englezakis,Jillian L. Barlow,Emily Hams,Seth T. Scanlon,Graham S. Ogg,Padraic G. Fallon,Padraic G. Fallon,Andrew N J McKenzie +13 more
TL;DR: During transition to adaptive T cell-mediated immunity, the ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production and identifies a previously unappreciated pathway in the regulation of type-2 immunity.
Journal ArticleDOI
Transcription factor RORα is critical for nuocyte development
See Heng Wong,See Heng Wong,Jennifer A. Walker,Helen E. Jolin,Lesley F Drynan,Emily Hams,Ana Camelo,Jillian L. Barlow,Daniel R. Neill,Daniel R. Neill,Veera Panova,Ute Koch,Freddy Radtke,Clare S. Hardman,You Yi Hwang,Padraic G. Fallon,Padraic G. Fallon,Andrew N J McKenzie +17 more
TL;DR: It is found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage.
Journal ArticleDOI
Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity
Jillian L. Barlow,Agustin Bellosi,Clare S. Hardman,Lesley F Drynan,See Heng Wong,James Cruickshank,Andrew N. J. McKenzie +6 more
TL;DR: These findings identify nuocytes as a novel cell type in allergic lung inflammation and an innate source of IL-13 that can directly induce AHR in the absence ofIL-13-producing CD4(+) T cells.
Journal ArticleDOI
Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma.
Sarah J. Ballantyne,Jillian L. Barlow,Helen E. Jolin,Puneeta Nath,Alison S. Williams,Kian Fan Chung,Graham Sturton,See Heng Wong,Andrew N. J. McKenzie +8 more
TL;DR: A novel pathway for the induction of AHR is defined and it is suggested that IL-25 represents an important therapeutic target for the treatment of asthma and blocks the binding of human IL- 25 to its receptor.