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Author

Seham A. Ibrahim

Bio: Seham A. Ibrahim is an academic researcher from Tanta University. The author has contributed to research in topics: Pyrazole & Dyeing. The author has an hindex of 8, co-authored 20 publications receiving 191 citations.
Topics: Pyrazole, Dyeing, Pyrazolone, Thiazole, Pyridine

Papers
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Journal ArticleDOI
TL;DR: Some new azo dye derivatives having pyrazole and trichlorotriazine moieties were synthesized and evaluated as reactive dyes for the exhaust dyeing of cotton fiber as discussed by the authors.

65 citations

Journal ArticleDOI
TL;DR: In this article, a series of new bis-thiazolyl-pyrazole derivatives 3, 4a-c, 5a, b, and 6a -c was synthesized by reacting bis hydrazonoyl bromide with several active methylene reagents in a one-pot reaction.

34 citations

Journal ArticleDOI
TL;DR: In this paper, a series of new magenta azomethine reactive disperse dyes were synthesized and applied into polyester/cotton blend fabrics, and various spectroscopic and analytical techniques characterized all the synthesized dyes.

33 citations

Journal ArticleDOI
TL;DR: 3-(Pyridin-3-yl)-1- p -tolyl-1 H -pyrazolo[3,4- d ]thiazol-5-amine was used as a key synthon for a one-pot two- and three-component synthesis of new fused heterocyclic moieties as pyrazole derivatives containing new fused ring pyrimidines or imidazoles to determine antitumor activity.
Abstract: 3-(Pyridin-3-yl)-1-p-tolyl-1H-pyrazolo[3,4-d]thiazol-5-amine was used as a key synthon for a one-pot two- and three-component synthesis of new fused heterocyclic moieties as pyrazolo[3,4-d]thiazole derivatives containing new fused ring pyrimidines or imidazoles. The compounds were synthesized by using microwave irradiation as an eco-friendly technique besides the conventional heating. All the newly synthesized compounds were characterized on the basis of their physical, spectral and analytical data. Most of the synthesized compounds were evaluated for their in vitro antimicrobial potentialities and antioxidant activities, and the most promising compounds were selected to determine antitumor activity. Molecular docking was performed inside the active site of cathepsin D, and target compounds 5a–c had a good binding energy of − 16.87 to − 11.64 kcal/mol compared to that of original ligand of − 16.02 kcal/mol with different binding interactions, thereby suggesting that these compounds may possibly act as cathepsin D inhibitors and thus may participate in anticancer activity.

29 citations

Journal ArticleDOI
TL;DR: In this paper, aryl amines were coupled with 3-substituted 5-amino pyrazoles to produce a series of novel 3substitized 5amino-4-arylazopyrazoles.

28 citations


Cited by
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Journal ArticleDOI
TL;DR: The different synthesis methods and the pharmacological properties of pyrazole derivatives developed by many scientists around the globe are highlighted.
Abstract: Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.

520 citations

Journal ArticleDOI
TL;DR: This review examines recent publications relating the structures of pyrazoles with their corresponding biological activities and approved pyrazole-containing drugs.

254 citations

Patent
17 Oct 2011
TL;DR: In this paper, the use of heterocyclic compounds, some of which are known, for controlling animal pests including arthropods and in particular insects, furthermore to novel HOC compounds and to processes for their preparation.
Abstract: The present application relates to the use of heterocyclic compounds, some of which are known, for controlling animal pests including arthropods and in particular insects, furthermore to novel heterocyclic compounds and to processes for their preparation.

103 citations

Journal ArticleDOI
TL;DR: A literature survey regarding the topics from the year 2015 up to now was carried out as mentioned in this paper, where nearly 124 research articles were found, critically analyzed, and arranged regarding the synthesis and biological activities of thiazoles derivatives in the last 5 years.
Abstract: Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal, antimalarial, anticancer, antiallergic, antihypertensive, anti-inflammatory, and antipsychotic. Indeed, the thiazole scaffold is contained in more than 18 FDA-approved drugs as well as in numerous experimental drugs. Objective: To summarize recent literature on the biological activities of thiazole ring-containing compounds Methods: A literature survey regarding the topics from the year 2015 up to now was carried out. Older publications were not included, since they were previously analyzed in available peer reviews. Results: Nearly 124 research articles were found, critically analyzed, and arranged regarding the synthesis and biological activities of thiazoles derivatives in the last 5 years.

73 citations

Journal ArticleDOI
TL;DR: Some new azo dye derivatives having pyrazole and trichlorotriazine moieties were synthesized and evaluated as reactive dyes for the exhaust dyeing of cotton fiber as discussed by the authors.

65 citations