A survey of the most recent progress in the biomedical applications of metal-containing polymers is given. Due to the unique optical, electrochemical, and magnetic properties, at least 30 different metal elements, most of them transition metals, are introduced into polymeric frameworks for interactions with biology-relevant substrates via various means. Inspired by the advance of metal-containing small molecular drugs and promoted by the great progress in polymer chemistry, metal-containing polymers have gained momentum during recent decades. According to their different applications, this review summarizes the following biomedical applications: (1) metal-containing polymers as drug delivery vehicles; (2) metal-containing polymeric drugs and biocides, including antimicrobial and antiviral agents, anticancer drugs, photodynamic therapy agents, radiotherapy agents and biocides; (3) metal-containing polymers as biosensors, and (4) metal-containing polymers in bioimaging.

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Metal-containing and related polymers for biomedical applications

Synthesis, Characterization and Biological Assay of Salicylaldehyde Schiff Base Cu(II) Complexes and their Precursors

Antimicrobial resistance challenged with metal-based antimicrobial macromolecules.

Ferrocenyl chalcone-based Schiff bases and their metal complexes: Highly efficient, solvent-free synthesis, characterization, biological research

Ferrocene-based Schiff bases copper (II) complexes: Synthesis, characterization, biological and electrochemical analysis

Synthesis, physicochemical studies and potential applications of high-molecular-weight ferrocene-based poly(azomethine)ester and its soluble terpolymers

In continuation to our efforts in finding potential therapeutic agents, a series of biologically significant poly(azomethine)esters (fe-PAME) were synthesized by the reaction of preformed (E)-4-((4-hydroxyphenylimino)methyl)phenol (SB) with 1,1-di(chlorocarboxyl)ferrocene, (PFe). Different aliphatic and aromatic sequences (1,3-propandiol, 1,6-hexandiol, and poly(dimethylsiloxane), hydroxyl-terminated (n = 550), 1,1,1,3,3,3-hexafluorobis(phenol)propane, and bisphenol A) were incorporated in the parent chain to study their effect on biological activity. The overall results led to the identification of some interesting polymers which seem to be potent antioxidants, highly cytotoxic, and more importantly DNA protecting and hence can be studied further for other pharmacological activities to be used as potential drug candidates. FTIR and 1H NMR spectroscopic studies and elemental analysis were used to establish structural elucidation and structure–property relations. Laser light scattering was used to determin...

Ferrocene-Based Aliphatic and Aromatic Poly(azomethine)esters: Synthesis, Physicochemical Studies, and Biological Evaluation

Synthesis, characterization and biological evaluation of ferrocene based poly(azomethene)esters

E3 ligases promote protein ubiquitination and degradation, which regulate every aspect of eukaryotic life. The Ariadne (ARI) proteins of RBR (ring between ring fingers) protein subfamily has been discovered as a group of potential E3 ubiquitin ligases. Only a few available research studies show their role in plant adaptations processes against the external environment. Presently, the functions of ARI proteins are largely unknown in plants. Therefore, in this study, we performed genome-wide analysis to identify the ARI gene family and explore their potential importance in B. napus. A total of 39 ARI genes were identified in the B. napus genome and were classified into three subfamilies (A, B and C) based on phylogenetic analysis. The protein–protein interaction networks and enrichment analysis indicated that BnARI genes could be involved in endoreduplication, DNA repair, proteasome assembly, ubiquitination, protein kinase activity and stress adaptation. The transcriptome data analysis in various tissues provided us an indication of some BnARI genes’ functional importance in tissue development. We also identified potential BnARI genes that were significantly responsive towards the abiotic stresses. Furthermore, eight BnARI genes were identified as candidate genes for multiple agronomic traits through association mapping analysis in B. napus; among them, BnaA02g12100D, which is the ortholog of AtARI8, was significantly associated with ten agronomic traits. This study provided useful information on BnARI genes, which could aid targeted functional research and genetic improvement for breeding in B. napus.

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Sehrish Sarfraz

Papers

Synthesis, physicochemical studies and potential applications of high-molecular-weight ferrocene-based poly(azomethine)ester and its soluble terpolymers

Ferrocene-Based Aliphatic and Aromatic Poly(azomethine)esters: Synthesis, Physicochemical Studies, and Biological Evaluation

Synthesis, characterization and biological evaluation of ferrocene based poly(azomethene)esters

Genome-Wide Identification and Analysis of Ariadne Gene Family Reveal Its Genetic Effects on Agronomic Traits of Brassica napus

Identification and comparative analysis of Histidine phosphotransfer (HP) genes reveal their role in cotton development and stress tolerance