S
Seiyu Hosono
Publications - 14
Citations - 2603
Seiyu Hosono is an academic researcher. The author has contributed to research in topics: Multiple displacement amplification & genomic DNA. The author has an hindex of 8, co-authored 14 publications receiving 2509 citations.
Papers
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Journal ArticleDOI
Comprehensive human genome amplification using multiple displacement amplification
Frank B. Dean,Seiyu Hosono,Linhua Fang,Xiaohong Wu,A. Fawad Faruqi,Patricia Bray-Ward,Zhenyu Sun,Qiuling Zong,Yuefen Du,Jing Du,Mark D. Driscoll,Wanmin Song,Stephen F. Kingsmore,Michael Egholm,Roger S. Lasken +14 more
TL;DR: MDA-based whole genome amplification by multiple displacement amplification is a simple and reliable method that could have significant implications for genetic studies, forensics, diagnostics, and long-term sample storage.
Journal ArticleDOI
Unbiased Whole-Genome Amplification Directly From Clinical Samples
Seiyu Hosono,A. Fawad Faruqi,Frank B. Dean,Yuefen Du,Zhenyu Sun,Xiaohong Wu,Jing Du,Stephen F. Kingsmore,Michael Egholm,Roger S. Lasken +9 more
TL;DR: Amplification of genomic DNA directly from cells is highly reproducible, eliminates the need for DNA template purification, and allows genetic testing from small clinical samples, compared with older, PCR-based methods.
Journal ArticleDOI
High-throughput genotyping of single nucleotide polymorphisms with rolling circle amplification
A. Fawad Faruqi,Seiyu Hosono,Mark D. Driscoll,Frank B. Dean,Osama Alsmadi,Rajanikanta Bandaru,Gyanendra Kumar,Brian Grimwade,Qiuling Zong,Zhenyu Sun,Yuefen Du,Stephen F. Kingsmore,Tim Knott,Roger S. Lasken +13 more
TL;DR: Compatibility with homogeneous formats and the ability to assay small amounts of genomic DNA meets the exacting requirements of automated, high-throughput SNP scoring.
Patent
Nucleic acid amplification
TL;DR: In this paper, it has been discovered that amplification reactions can produce amplification products of high quality, such as low amplification bias, if performed on an amount of nucleic acid at or over a threshold amount and/or on nucleic acids at or below a threshold concentration.
Patent
Multiple displacement amplification
Frank B. Dean,Roger S. Lasken,Linhua Fang,A. Fawad Faruqi,Osama Alsmadi,Mark D. Driscoll,Seiyu Hosono +6 more
TL;DR: In this article, a method for multiple displacement amplification of nucleic acid sequences of interest is described, in which the replicated strands are displaced from the target sequence by strand displacement replication of another replicated strand.