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Sejal Doshi

Bio: Sejal Doshi is an academic researcher from Indian Institute of Technology Bombay. The author has contributed to research in topics: Graphene & Langmuir adsorption model. The author has an hindex of 7, co-authored 8 publications receiving 287 citations.

Papers
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TL;DR: Graphene manganese ferrite (MnFe2O4-G) composite was prepared by a solvothermal process and tested for the adsorption of lead (Pb) and cadmium (Cd(II)) ions by analytical methods under diverse experimental parameters as mentioned in this paper.

135 citations

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TL;DR: Graphene-Fe3O4 (G-Fe 3O4) composite was prepared from graphene oxide (GO) and FeCl3·6H2O by a one-step solvothermal route as discussed by the authors.
Abstract: Graphene–Fe3O4 (G–Fe3O4) composite was prepared from graphene oxide (GO) and FeCl3·6H2O by a one-step solvothermal route. The as-prepared composite was characterized by field-emission scanning electron microscopy, transmission electron microscopy, dynamic light scattering and X-ray powder diffraction. SEM analysis shows the presence of Fe3O4 spheres with size ranging between 200 and 250 nm, which are distributed and firmly anchored onto the wrinkled graphene layers with a high density. The resulting G–Fe3O4 composite shows extraordinary adsorption capacity and fast adsorption rates for the removal of Pb metal ions and organic dyes from aqueous solution. The adsorption isotherm and thermodynamics were investigated in detail, and the results show that the adsorption data was best fitted with the Langmuir adsorption isotherm model. From the thermodynamics investigation, it was found that the adsorption process is spontaneous and endothermic in nature. Thus, the as-prepared composite can be effectively utilized for the removal of various heavy metal ions and organic dyes. Simultaneously, the photodegradation of methylene blue was studied, and the recycling degradation capacity of dye by G–Fe3O4 was analyzed up to 5 cycles, which remained consistent up to ∼97% degradation of the methylene blue dye. Although iron oxide has an affinity towards bacterial cells, its composite with graphene still show antibacterial property. Almost 99.56% cells were viable when treated with Fe3O4 nanoparticle, whereas with the composite barely 3% cells survived. Later, the release of ROS was also investigated by membrane and oxidative stress assay. Total protein degradation was analyzed to confirm the effect of the G–Fe3O4 composite on E. coli cells.

104 citations

Journal ArticleDOI
TL;DR: The kinetic models suggest that the release of cefotaxime is dependent on the dissolution and diffusion of drug molecules in the physiological medium and both Cefo-LDH and the CLF nanohybrid are seen to be biocompatible with murine fibroblast cells.
Abstract: In the current work, we report the loading of cefotaxime sodium on Mg–Al layered double hydroxide (Cefo-LDH) and the formation of a nanohybrid with a fenugreek polymer (CLF nanohybrid). This nanohybrid was synthesized through the method of anion-exchange followed by sonication. The as-synthesized CLF nanohybrid was thoroughly characterized by XRD, FTIR and zeta potential measurements, which revealed that the cefotaxime drug was bound to the LDH surface. The drug loading capacities of Cefo-LDH and the CLF nanohybrid were found to be 85.6 and 72.5 μg mg−1, respectively. The drug released from the CLF nanohybrid demonstrates a controlled and sustained profile at pH 7.3 over a period of 72 h. The mechanism of drug release is explained by the first-order and parabolic kinetic models. The kinetic models suggest that the release of cefotaxime is dependent on the dissolution and diffusion of drug molecules in the physiological medium. At a concentration up to 1 mg mL−1, both Cefo-LDH and the CLF nanohybrid are seen to be biocompatible with murine fibroblast (L929) cells. Furthermore, antibacterial activity studies against the cefotaxime drug-resistant Escherichia coli (E. coli) strain show about 98% cell mortality with 1 mg mL−1 of the nanohybrid loaded with cefotaxime.

23 citations

Journal ArticleDOI
TL;DR: The present study clearly demonstrates the advantage of the luminescent apo-α-LA-AuNPs in their attack ofcancer cells in general and selective killing of breast cancer cells in particular.
Abstract: A green synthesis was developed in order to prepare protein coated gold nanoparticles using a metal free, α-helical protein, i.e., apo-α-LA, that acts as both the reducing as well as stabilizing agent to result in Au0 nanoparticles from Au3+ which are luminescent and hence can be used for biological imaging, including of cells. The nanoparticles, apo-α-LA-AuNPs, thus synthesized were characterized by multiple techniques, such as, analytical, spectral, microscopy and light scattering, in order to support the presence of NPs in terms of their size and shape, involvement of Au0 and the protein encapsulation and its structural changes upon coating. The 10–16 nm sized apo-α-LA-AuNPs were shown to be non-toxic to healthy cells as studied using normal mouse fibroblast cells (L929). Having found that these NPs are biocompatible and possess structurally altered apo-α-LA protein, the luminescent apo-α-LA-AuNPs were demonstrated to have cytotoxicity towards cancer cells as studied by cell viability tests as well as fluorescence microscopy. While these NPs kill ∼75% of MCF-7 cells, at the same concentration these are capable of killing only ∼30% of HeLa cells, thus exhibiting cell dependency. The present study clearly demonstrates the advantage of the luminescent apo-α-LA-AuNPs in their attack of cancer cells in general and selective killing of breast cancer cells in particular. Thus coating AuNPs with the protein apo-α-LA enhanced their anticancer activity several fold.

21 citations

Journal ArticleDOI
TL;DR: Graphene oxide (GO) has been reduced using Gram-negative facultative anaerobe S. dysenteriae, having exogenic properties of electron transfer via electron shuttling and an effective role of lipopolysaccharide has been observed while comparing RGO reduced by S. aureus.
Abstract: Reduced graphene oxide (RGO) has been prepared by a simple, cost-effective, and green route. In this work, graphene oxide (GO) has been reduced using Gram-negative facultative anaerobe S. dysenteriae, having exogenic properties of electron transfer via electron shuttling. Apparently, different concentrations of GO were successfully reduced with almost complete mass recovery. An effective role of lipopolysaccharide has been observed while comparing RGO reduced by S. dysenteriae and S. aureus. It was observed that the absence of lipopolysaccharide in Gram-positive S. aureus leads to a disrupted cell wall and that S.aureus could not survive in the presence of GO, leading to poor and inefficient reduction of GO, as shown in our results. However, S. dysenteriae having an outer lipopolysaccharide layer on its cell membrane reduced GO efficiently and the reduction process was extracellular for it. RGO prepared in our work has been characterized by X-ray diffraction, ζ potential, X-ray photoelectron spectroscopy,...

15 citations


Cited by
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Journal ArticleDOI
TL;DR: In this article, various nanomaterials have been reviewed which have been used for water decontamination and a review has been given on adsorption, photocatalytic and antibacterial activity of nanommaterials.

910 citations

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TL;DR: In this article, the authors discuss the current development of graphene-based metal and metal oxide nanocomposites, with a detailed account of their synthesis and properties, including their applications in various fields including electronics, electrochemical and electrical fields.
Abstract: Graphene, an atomically thin two-dimensional carbonaceous material, has attracted tremendous attention in the scientific community, due to its exceptional electronic, electrical, and mechanical properties. Indeed, with the recent explosion of methods for a large-scale synthesis of graphene, the number of publications related to graphene and other graphene based materials has increased exponentially. Particularly the development of easy preparation methods for graphene like materials, such as highly reduced graphene oxide (HRG) via reduction of graphite oxide (GO), offers a wide range of possibilities for the preparation of graphene based inorganic nanocomposites by the incorporation of various functional nanomaterials for a variety of applications. In this review, we discuss the current development of graphene based metal and metal oxide nanocomposites, with a detailed account of their synthesis and properties. Specifically, much attention has been given to their wide range of applications in various fields, including electronics, electrochemical and electrical fields. Overall, by the inclusion of various references, this review covers in detail the aspects of graphene-based inorganic nanocomposites.

530 citations

Journal ArticleDOI
TL;DR: Spinel ferrite (SF) magnetic materials are an important class of composite metal oxides containing ferric ions and having the general structural formula M 2+ Fe 2 3+ O 4.

523 citations

Journal ArticleDOI
TL;DR: This review elucidate FGNs-bioorganism interactions and summarize recent advancements on designing FGN-based two-dimensional and three-dimensional architectures as multifunctional biological platforms.
Abstract: Functional graphene nanomaterials (FGNs) are fast emerging materials with extremely unique physical and chemical properties and physiological ability to interfere and/or interact with bioorganisms; as a result, FGNs present manifold possibilities for diverse biological applications. Beyond their use in drug/gene delivery, phototherapy, and bioimaging, recent studies have revealed that FGNs can significantly promote interfacial biointeractions, in particular, with proteins, mammalian cells/stem cells, and microbials. FGNs can adsorb and concentrate nutrition factors including proteins from physiological media. This accelerates the formation of extracellular matrix, which eventually promotes cell colonization by providing a more beneficial microenvironment for cell adhesion and growth. Furthermore, FGNs can also interact with cocultured cells by physical or chemical stimulation, which significantly mediate their cellular signaling and biological performance. In this review, we elucidate FGNs–bioorganism int...

405 citations

Journal ArticleDOI
TL;DR: The antibacterial mechanism of graphene is highlighted and recent advances related to the antibacterial activity of graphene-based materials are summarized and many of the recent application examples are further discussed.

399 citations