Selvakumar Murugesan

Bio: Selvakumar Murugesan is an academic researcher from Anna University. The author has contributed to research in topics: Cissus quadrangularis & ABTS. The author has an hindex of 6, co-authored 20 publications receiving 146 citations. Previous affiliations of Selvakumar Murugesan include Central Food Technological Research Institute & Bharathidasan University.

A Facile Green Approach of Cone-like ZnO NSs Synthesized Via Jatropha gossypifolia Leaves Extract for Photocatalytic and Biological Activity

Abstract: In the present work, cone-like zinc oxide (ZnO) nanostructures (NSs) were fabricated via a simple green approach by Jatropha gossypifolia leaves extract for improving the photocatalytic and biological activity. The crystallinity and surface morphology of synthesized NPs were characterized by powder X-ray diffraction (PXRD) and transmission electron microscopic (TEM) analysis. The presence of elements in the prepared ZnO NSs was determined by the energy dispersive X-ray (EDX) spectroscopy. The photocatalytic activities of ZnO NSs were investigated by the removal of methylene blue (MB) and malachite green (MG) organic dyes under UV light irradiation. The result demonstrates that the organic dye degradation efficiency of the MG and MB was achieved at 96% and 82% under UV light irradiation. The green synthesized ZnO NSs demonstrate superior antibacterial activity against gram-positive and gram-negative bacteria's and it has excellent antioxidant ABTS free radical scavenging activity. The inhibition of denaturation of protein and proteinase inhibitory was studied by anti-arthritic activity.

Nutritional and therapeutic benefits of medicinal plant Pithecellobium dulce (Fabaceae): A review -

Abstract: Pithecellobium dulce, an evergreen medium-sized, spiny tree, each part of the plant has vast nutritional values; stuffed with essential vitamins, amino acids and minerals. The fruits of P. dulce, widely used in Ayurvedic medicines and home remedies. The plant has also been a rich source of biologically active compounds such as tannin, olein and glycosides. Totally 38 active phytocompounds like quercetin, kaemferol, dulcitol were identified from the various parts of the plant. Notably, this plant has catechol type of tannins in bark. There are polyphenol classes of phytocompounds which have found to be hold potent an antivenom activity. Their fruits are rich source of phenols, flavonoids and saponins reported for their efficacy to treat diabetes, oxidative stress, and gastrointestinal disorders. The plant leaf and seed have an antibacterial, antifungal and adulticidal activities. Thus, the present review describes on exploiting the medicinal properties of P. dulce and its biomedicinal applications in therapeutic development.

Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques.

Abstract: Prosthesis-associated infections are one of the main causes of implant failure; thus it is important to enhance the long-term antibacterial ability of orthopedic implants. Titanium dioxide nanotubes (TNTs) are biomaterials with good physicochemical properties and biocompatibility. Owing to their inherent antibacterial and drug-loading ability, the antibacterial application of TNTs has received increasing attention. In this review, the process of TNT anodizing fabrication is summarized. Also, the mechanism and the influencing factors of the antibacterial property of bare TNTs are explored. Furthermore, different antibacterial strategies for carrying drugs, as well as modifications to prolong the antibacterial effect and reduce drug-related toxicity are discussed. In addition, antibacterial systems based on TNTs that can automatically respond to infection are introduced. Finally, the currently faced problems are reviewed and potential solutions are proposed. This review provides new insight on TNT fabrication and summarizes the most advanced antibacterial strategies involving TNTs for the enhancement of long-term antibacterial ability and reduction of toxicity.

Grape Seed Proanthocyanidin Extract Mitigates Titanium Dioxide Nanoparticle (TiO2-NPs)-Induced Hepatotoxicity Through TLR-4/NF-κB Signaling Pathway.

Abstract: With the progress of nanotechnology, the adverse effects of nanoscale materials are receiving much attention. Inhibition of toll-like receptor 4 (TLR-4)/nuclear factor kappa B (NF-κB) signaling is a hallmark for downregulating the expression of many inflammatory genes implicated in oxidative stress. Therefore, the present study aimed to demonstrate the influence of grape seed proanthocyanidin extract (GSE) on the hepatic TLR-4/ NF-κB signaling pathway in TiO2-NP-induced liver damage in rats. Forty male Albino rats were divided into 4 groups (n = 10): G1 was used as a control, G2 received TiO2-NPs (500 mg/kg/day orally) from the 17th to 30th day (acute toxicity), G3 received GSE (75 mg/kg/day orally) for 30 days, and G4 pre- and co-treated with GSE (for 30 days) and TiO2-NPs (from the 17th to 30th day), with the aforementioned doses. TiO2-NPs induced severe hepatic injury that was indicated by biochemical alterations in serum liver markers (acetylcholinesterase, ALT, ALP, total proteins, albumin, and direct bilirubin), oxidative stress indicators (MDA, GSH, and catalase), and histopathological alterations as well. Moreover, TiO2-NPs triggered an inflammatory response via the upregulation of TLR-4, NF-κB, NIK, and TNF-α mRNA expressions. Pre- and co-treatments with GSE alleviated the detrimental effects of TiO2-NPs which were enforced by the histopathological improvements. These results indicated that GSE effectively protected against TiO2-NP-induced hepatotoxicity via the inhibition of TLR-4/NF-κB signaling and hence suppressed the production of pro inflammatory cytokines such as TNF-α and improved the antioxidant status of the rats.